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IFOM-KU International Joint Lab
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The lab investigates how cancer arises by studying abnormalities in telomeres, the ends of chromosomes.
AboutAbout the lab
Understanding cancer through chromosomal abnormalities.
The IFOM-KU International Joint Lab was jointly established by Kyoto University Graduate School of Medicine and the IFOM Institute of Molecular Oncology in Italy, and its research is conducted on the Graduate School of Medicine campus.
Focusing on the function of telomeres at the ends of chromosomes, the lab uses methods such as genome editing and imaging to understand how chromosomal abnormalities lead to the malignant transformation of cells and to increased malignancy in cancer cells.
Master's and doctoral students each work on independent research topics, international students are part of the lab, and seminars are held mainly in English.
Key terms
- Telomere
- A complex of DNA and proteins at the end of a chromosome that protects the chromosome end
- Chromosome fusion
- The joining of chromosome ends to one another, which can lead to cell death or malignant transformation
- Genome editing
- A technology for cutting or rewriting DNA at a targeted location
ResearchResearch themes
In the short term, chromosomal abnormalities lead directly to cell death and cellular dysfunction, and in the long term they are also involved in the evolution of life.
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MembersFaculty
- Visiting Associate ProfessorMakoto Hayashi
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Chromatin bridges viewed using immunofluorescence” Hrz2 / CC BY-SA 3.0 (cropped)
- How chromosome fusion determines cell fate: “Tradescantia Chromatid Anaphase Bridge induced by X-rays” Luippold / CC BY 4.0 (cropped)
- Related lab (Mathematical Biomedicine Lab): “Mast Cell (NIH BioArt )” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Related lab (Health and Aging Medicine Lab): “OrbisPictus b 158” Johann Amos Comenius / Public domain (cropped)
- Related lab (Educational Neuroscience Lab): “Hitane Elementary School classroom 3” Douglas P Perkins / CC BY 3.0 (cropped)
- Related lab (Advanced Medicine for Rheumatic Diseases Lab): “Rheumatoid arthritis with carpal ankylosis 2017” Mikael Häggström / CC0 (cropped)
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