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Mathematical Biomedicine Lab
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The lab uses mathematics and AI to decipher differences between diseases from limited patient data.
AboutAbout the lab
Understanding patient-to-patient differences through a mathematical lens
The lab combines mathematical modeling, topological data analysis, optimal transport, AI, bioinformatics, and clinical data to build a research foundation for understanding disease mechanisms and differences between individual patients from a limited number of patient samples.
This work is set against the rapid development of quantitative technologies that support the life sciences, such as multi-omics analysis, organoids, and in vivo imaging inside the living body.
The lab places importance on training researchers who understand both medicine/life sciences and mathematical/information sciences, and who can bridge these fields to pose new questions.
Key terms
- Mathematical model
- A description of how a phenomenon works, expressed in mathematical equations. Used for purposes such as predicting change.
- Multi-omics
- An approach that examines the molecules in the body, such as genes, proteins, and metabolites, together across multiple layers.
- Chronic urticaria
- A skin disease in which itchy raised welts (wheals) appear repeatedly over a long period.
ResearchResearch themes
The lab studies inflammatory and immune-mediated diseases from multiple angles, advancing research that spans basic research, clinical medicine, drug discovery, and implementation in society.
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MembersFaculty
- ProfessorSungrim Seirin-Seirin-Lee
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Mast Cell (NIH BioArt )” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Understanding inflammatory and immune diseases through data and mathematical models: “Mast Cell (NIH BioArt )” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Related lab (ファーマコメトリクス・システム薬理学): “Infusion pump 2” Senior Airman Andrea Posey/U.S. Air Force / Public domain (cropped)
- Related lab (臨床統計学): “Box Plot Picture” The Twists and Turns / CC0 (cropped)
- Related lab (IFOM-KU国際共同ラボ): “Chromatin bridges viewed using immunofluorescence” Hrz2 / CC BY-SA 3.0 (cropped)
- Related lab (リウマチ性疾患先進医療学): “Rheumatoid arthritis with carpal ankylosis 2017” Mikael Häggström / CC0 (cropped)
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