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Health and Aging Medicine Lab
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The lab investigates the mechanisms of aging and age-related diseases over time, from molecules to whole organisms.
AboutAbout the lab
Taking on the mysteries of aging and senescence with curiosity.
The lab introduces the latest findings in aging medicine and trains the next generation of researchers in the field of health and aging medicine.
The lab teaches research methods for systematically investigating aging over time, from the molecular level to the whole organism, and also teaches the fundamentals of imaging and mathematical analysis models and the development of new technologies and instruments.
The lab places importance on sharpening the ability to "discover problems" and on tackling unique research that others do not pursue, with curiosity and a spirit of inquiry.
Key terms
- Epigenome
- The complete set of marks attached to DNA and related molecules, as distinct from the DNA sequence itself. It determines which genes are active.
- Senescence
- The gradual decline in the body's functions as a person grows older.
- Biomarker
- A substance in the body that provides clues about the state of a disease.
ResearchResearch themes
The lab's research rests on three pillars: the mechanisms of aging and senescence, how time progresses from organ development to senescence, and the assessment of cognitive function and the diagnosis of dementia.
*Illustrative imageMechanisms of Aging and Senescence
The lab analyzes how lifelong nutrition and environment, the pace at which time progresses, epigenomic state, and other factors affect the speed of aging, senescence, and the onset of disease, with the aim of clarifying the mechanisms of aging behind them.
*Illustrative imageControl of Time from Organ Development to Senescence
Focusing on the processes of development and maturation, in which organs and tissues form and their size and function are determined, and on the process of senescence, in which they decline, the lab investigates the factors that control how time progresses in each process and how disruption of that control relates to age-related diseases.
*Illustrative imageAssessment of Cognitive Function and Dementia Research
The lab is developing and promoting a large-scale cognitive function assessment system using AI technology, working to clarify the mechanisms of Alzheimer's disease, and developing new diagnostic systems based on a variety of biomarkers.
MembersFaculty
- Project ProfessorYoichi Nabeshima
- Project ProfessorFumio Matsuzaki
- Program-Specific ProfessorYoshihiro Uto
- Program-Specific LecturerMayumi Mori
- Program-Specific LecturerQuan Wu
- Program-Specific Assistant ProfessorChiaki Abe
- Program-Specific Assistant ProfessorHirofumi Sogabe
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “OrbisPictus b 158” Johann Amos Comenius / Public domain (cropped)
- Mechanisms of Aging and Senescence: “Elderly Man's Hands ( )” Tony Alter from Newport News, USA / CC BY 2.0 (cropped)
- Control of Time from Organ Development to Senescence: “Antique watch with stackfreed” 作者不詳 / Public domain (cropped)
- Assessment of Cognitive Function and Dementia Research: “Cerebellum mri” Ingvald3 / CC BY-SA 4.0 (cropped)
- Related lab (Gastrointestinal Tumor Control and Organ Regeneration Surgery Lab): “Plastic Surgeon Performing Surgery in Operating Room” Tyler Frew MD / CC BY-SA 4.0 (cropped)
- Related lab (Drug Discovery Medicine Lab): “Automated Screening ( )” National Center for Advancing Translational Sciences from Bethesda, MD / Public domain (cropped)
- Related lab (Educational Neuroscience Lab): “Hitane Elementary School classroom 3” Douglas P Perkins / CC BY 3.0 (cropped)
- Related lab (IFOM-KU International Joint Lab): “Chromatin bridges viewed using immunofluorescence” Hrz2 / CC BY-SA 3.0 (cropped)
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