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Clinical Cancer Immunology and Pharmacology Lab
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A lab that develops new cancer treatments by targeting weaknesses that arise from genetic changes in cancer cells.
AboutAbout the lab
Targeting cancer's weaknesses to cure hard-to-treat cancers.
The Clinical Cancer Immunology and Pharmacology Lab focuses on vulnerabilities that arise from genetic alterations in cancer cells (such as KRAS and TP53), and researches and develops new molecularly targeted therapies and immunotherapies.
Aiming to completely cure hard-to-treat cancers, such as unresectable gastrointestinal cancers, the lab works to develop effective and safe treatments tailored to each patient.
The lab welcomes researchers and graduate students from Japan and abroad, including those who hope to study overseas in the future.
The lab is a division of the Center for Cancer Immunotherapy and Immunobiology.
Key terms
- Molecularly targeted therapy
- Treatment using drugs that act by targeting specific molecules in cancer cells
- Tumor suppressor gene
- A gene that helps prevent cells from becoming cancerous. TP53 is one example
- Biomarker
- A substance in the body that provides clues about the state of a disease or how well a drug is working
ResearchResearch themes
The genetic changes that cause cells to become cancerous are complex, but comprehensive genetic analysis has been clarifying how frequent they are and what they do. Aiming for treatments that act strongly on cancer cells while limiting effects on normal cells, the lab focuses on developing therapies that target proteins related to oncogenes such as KRAS and tumor suppressor genes such as TP53.
*Illustrative imageSearching for new treatments through screening
Using genome-wide CRISPR-Cas9 screening and compound screening, the lab searches for new molecularly targeted therapies and cancer immunotherapies.
*Illustrative imageAnalyzing why drugs work or fail
Using mouse models and clinical specimens, the lab analyzes the factors that make molecularly targeted therapies and immunotherapies work and the factors that cause them to stop working, aiming to develop drugs that make these treatments more effective.
*Illustrative imageDeveloping biomarkers in collaboration with the biobank
In collaboration with the Clinical Bio-Resource Center (biobank) at Kyoto University Hospital, the lab collects specimens and clinical information, and develops and validates biomarkers that indicate the effectiveness and safety of cancer immunotherapy.
MembersFaculty
- Associate ProfessorOsamu Kikuchi
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “CSIRO ScienceImage 1521 iPS cells in the lab” , CSIRO / CC BY 3.0 (cropped)
- Searching for new treatments through screening: “Peptide bound to Rituximab FAB” Simon Caulton / CC BY-SA 3.0 (cropped)
- Analyzing why drugs work or fail: “Mechanisms of resistance to immunotherapy” Fen Wang,Shubin Wang.Qing Zhou / CC BY 4.0 (cropped)
- Developing biomarkers in collaboration with the biobank: “Empty sample storage cases in Estonia Biobank” Koidres / CC BY 4.0 (cropped)
- Related lab (がん免疫治療): “Dendritic Cell (NIH BioArt )” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Related lab (がん免疫多細胞システム制御): “Dendritic Cell (NIH BioArt )” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Related lab (口腔外科学): “Dental Implant Key Terms” 95Berlin / CC BY-SA 2.5 (cropped)
- Related lab (医学統計生物情報学): “Scholia - Clinical trials overview - 2021-12 - Phases” Wikimedia Community / CC BY-SA 4.0 (cropped)
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