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Laboratory Animal Science Lab
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A lab that creates human-mimicking animal models with genome editing, connecting them to understanding disease and to medicine.
AboutAbout the lab
Understanding life and connecting it to medicine through human-mimicking models.
The Laboratory Animal Science Lab (Yoshimi Lab) is built around the question of how far human biological phenomena can be reproduced in animals, and conducts research using animal models that mimic humans.
Building on genome editing technologies such as CRISPR-Cas, the lab develops "genome-humanized models," in which regions of human genes are inserted into the animal genome, as well as technologies for rewriting large regions of the genome.
It is a new lab established in April 2026 at the Institute of Laboratory Animals, Graduate School of Medicine.
The lab accepts students from the Department of Medicine and the Department of Medical Science in the Graduate School, and welcomes lab visits and inquiries at any time.
Key terms
- Genome editing
- A technology for cutting or rewriting targeted sites in DNA. CRISPR-Cas9 and others are used.
- Genome-humanized model
- A laboratory animal in which part of the animal's genes has been replaced with a region of human genes.
- CRISPR-Cas3
- One of the genome editing tools that use a bacterial immune mechanism. It is good at deleting long stretches of DNA.
NewsLab news
Report of a new way to tune CRISPR-Cas3, which excels at large DNA deletions
Prof. Hirano selected as an Assistant Professor under the Young Researcher Priority Strategy Positions
Professor Yoshimi takes up the post and opens the lab
ResearchResearch themes
By combining laboratory animal science with genome editing technologies, and by also developing the technologies for manipulating the genome itself, the lab aims to reproduce biological phenomena at a new scale and precision, connecting an understanding of the essence of disease to medical applications.
*Illustrative imageGenome humanization using genome editing
To create models for studying how human genes function in the body, the lab will pursue research on inserting human gene regions into animals through genome editing.
*Illustrative imageNext-generation genome manipulation technologies
Building on a new genome editing technology that uses CRISPR-Cas3, the lab aims to develop a tool that can perform genome editing, epigenome editing, and genome imaging simultaneously.
*Illustrative imageInteractions between hosts and microbes or viruses
Using genome editing and humanized animal models, the lab studies interactions between hosts and microbes or viruses.
*Illustrative imageExpanding and making use of laboratory rats
The lab creates genetically modified rat models with genome editing and expands the rat resources available to researchers. Kyoto University is the core institution of NBRP-Rat, a global hub for rat resources.
MembersFaculty
The Laboratory Animal Science Lab (Yoshimi Lab) is made up of faculty, project researchers, project staff and administrative staff, graduate students, and research students.As of 2026
- ProfessorKazuto Yoshimi
- LecturerJumpei Taguchi
- Program-Specific LecturerAsahi Haijima
- Assistant ProfessorTomoko Matsuzaki
- Assistant ProfessorRika Hirano
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Eppendorf pipet” Jucember / CC BY-SA 3.0 (cropped)
- Genome humanization using genome editing: “XBio illustration – Genome Editing” explorebiology / CC BY 4.0 (cropped)
- Next-generation genome manipulation technologies: “Overview of TALENs” Ogletreerd / CC BY-SA 4.0 (cropped)
- Interactions between hosts and microbes or viruses: “Macrophage Infected with Francisella tularensis Bacteria ( )” NIAID / CC BY 2.0 (cropped)
- Expanding and making use of laboratory rats: “Scientist with laboratory rats, from an advertisement for Fleischmann’s yeast” 作者不詳 / Public domain (cropped)
- Related lab (Pathophysiological Biomedicine Lab): “Oxford Nanopore Technologies Mk1c” Rojoxiii / CC0 (cropped)
- Related lab (Diabetes, Endocrinology and Nutrition Lab): “Suckale08 fig2 islet structure” Jakob Suckale, Michele Solimena / CC BY 3.0 (cropped)
- Related lab (Disease Genome Epidemiology and Genome Informatics Lab (Center for Genomic Medicine)): “Hokkoku Kaido, Nagahama 05” Sachi0myk / CC BY-SA 4.0 (cropped)
- Related lab (Higher-Order Inter-System Regulation Lab): “Mitochondria, mammalian lung - TEM” Louisa Howard / Public domain (cropped)
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