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Otolaryngology-Head and Neck Surgery Lab
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A lab aiming to restore the senses and functions of the ear and throat through regenerative medicine.
AboutAbout the lab
Restoring hearing, speech, and swallowing through regenerative medicine.
The lab treats a wide range of diseases of the head and neck as a whole. Its main research focuses on senses such as hearing, balance, smell, and taste, and on functions such as breathing, swallowing, and vocalization.
Through regeneration of inner ear sensory cells and the eardrum using regenerative medicine, and through the development of systems that deliver drugs to the inner ear, the lab aims to create new treatments for inner ear hearing loss.
The lab is also advancing airway regeneration using artificial tracheas and iPS cells, research on tissue stem cells of the larynx, and the development of robots to support precise surgery.
This lab has an endowed chair, the Department of Advanced Therapeutics for Head and Neck Tumors.
Key terms
- Inner ear
- The organ deep in the ear that senses sound and the tilt of the body
- Hair cells
- Sensory cells with hair-like projections in the inner ear that detect sound and movement
- Organoid
- A small three-dimensional tissue resembling an organ, grown in vitro from stem cells or similar cells
ResearchResearch themes
The lab advances basic and clinical research on diseases of the ear and the head and neck, centered on regenerative medicine, and actively pursues collaborative research across fields.
*Illustrative imageResearch on Inner Ear Regeneration, and on Hearing Loss and the Brain
The mammalian inner ear, once damaged after birth, never recovers for the rest of life. The lab works to elucidate the mechanisms of inner ear development and regeneration, and also conducts comparative studies with bird models, which are able to regenerate hair cells.
*Illustrative imageRegenerative Medicine for the Larynx and Trachea
To overcome hoarseness and breathing disorders, the lab studies regenerative medicine based on tissue engineering. Through analysis of laryngeal cells and the creation of organoids, it searches for the cells that serve as the starting point of regeneration.
MembersFaculty
- ProfessorIchiro Tateya
- Associate ProfessorYo Kishimoto
- LecturerTsuyoshi Kojima
- LecturerKoji Nishimura
- Program-Specific LecturerHiroe Ohnishi
- Assistant ProfessorYosuke Tona
- Assistant ProfessorYoshitaka Kawai
- Assistant ProfessorShintaro Fujimura
- Assistant ProfessorMami Matsunaga
- Assistant ProfessorKen Iwanaga
- Assistant ProfessorYasuharu Haku
- Assistant ProfessorAkira Yoshizawa
- Program-Specific Hospital Assistant ProfessorAtsushi Taguchi
- LecturerHiroshi Yamazaki
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Cochlea showing hair cells ( )” eLife - the journal / CC BY 2.0 (cropped)
- Research on Inner Ear Regeneration, and on Hearing Loss and the Brain: “Analysis of cochlear hair cells and their stereocilia. cropped” Lorente-Cánovas B, Eckrich S, Lewis MA, Johnson SL, Marcotti W, Steel KP / CC BY 4.0 (cropped)
- Regenerative Medicine for the Larynx and Trachea: “Anatomytool larynx and vocal cords English” Cenveo / CC BY 4.0 (cropped)
- Related lab (Plastic and Reconstructive Surgery Lab): “Keratinocytes in spinous layer of epidermis” Dr. Roshan Nasimudeen / CC BY-SA 3.0 (cropped)
- Related lab (Diabetes, Endocrinology and Nutrition Lab): “Suckale08 fig2 islet structure” Jakob Suckale, Michele Solimena / CC BY 3.0 (cropped)
- Related lab (Molecular and Cellular Physiology Lab): “Taste bud esp” NEUROtiker / CC BY-SA 3.0 (cropped)
- Related lab (Molecular Cell Informatics Lab): “Platform for protein crystallography and X-ray scattering” Evgeny Pelevin / CC BY 4.0 (cropped)
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