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Advanced Cardiovascular Therapeutics Lab
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The lab investigates myokines secreted by skeletal muscle and ways to make arrhythmia treatment safer.
AboutAbout the lab
Exploring substances released by muscle and treatments for arrhythmia
The lab studies the actions of substances secreted by skeletal muscle and the safety of arrhythmia treatment.
It is an endowed department of the Graduate School of Medicine, and the Graduate School's page lists arrhythmia, pacemakers, heart failure, and clinical research as its fields.
Project Professor Noriyuki Ochi focuses on myokines, whose levels change with exercise and aging, and investigates their roles in age-related diseases such as sarcopenia and chronic heart failure.
Project Lecturer Satoshi Yanagisawa studies microemboli that occur during catheter ablation for arrhythmia, seeking safer treatment methods.
Key terms
- Myokine
- A factor secreted by skeletal muscle. Its levels change with exercise, physical inactivity, and aging.
- Sarcopenia
- A condition in which muscle mass decreases and muscle strength declines with aging.
- Catheter ablation
- A treatment in which a catheter inserted into the heart applies energy to the area that causes an arrhythmia.
- Microemboli
- Very small air bubbles or particles carried in the bloodstream. If they travel to the brain, they can cause silent cerebral infarction.
ResearchResearch themes
The lab studies heart and vascular diseases and the age-related diseases associated with them, from both molecular and clinical perspectives. It investigates the actions of myokines secreted by skeletal muscle, and conducts clinical research to make catheter treatment of arrhythmia safer.
*Illustrative imageMyokines and Age-Related Diseases
The lab investigates, at the whole-organism and cellular levels, the roles that myokines (secreted factors derived from skeletal muscle whose levels change with exercise and aging) play in age-related diseases such as sarcopenia, chronic heart failure, and chronic kidney failure (Project Professor Ochi). It has shown that myonectin, which increases with exercise, has a protective effect on skeletal muscle.
*Illustrative imageInvestigating Microemboli During Arrhythmia Treatment
Using a dedicated carotid ultrasound device that can visualize microemboli, the lab examines microemboli that occur during catheter ablation for arrhythmia. It is conducting clinical research comparing differences by power output, and is also studying differences by catheter type together with other institutions, aiming to establish safer and more effective treatment (Project Lecturer Yanagisawa).
MembersFaculty
- Project ProfessorNoriyuki Ochi
- Project LecturerSatoshi Yanagisawa
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Health Health - Stethoscope” formulatehealth / CC BY 2.0 (cropped)
- Myokines and Age-Related Diseases: “Skeletal Muscle Tissue” Community College Bioscience / CC0 (cropped)
- Investigating Microemboli During Arrhythmia Treatment: “Herzkatheterlabor” Wolfgang Hunscher, Dortmund / CC BY-SA 3.0 (cropped)
- Related lab (Molecular Cell Biology Lab (Anatomy I)): “Observing Ocular Tissue under Laser Scanning Microscope ( )” National Eye Institute / CC BY 2.0 (cropped)
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