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Functional Histology Lab (Anatomy II)
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A lab that explores how neurons respond to damage, in order to understand how they are protected and repaired.
AboutAbout the lab
Exploring the mechanisms of protection and repair through the neuronal response to damage
The lab studies how neurons respond to damage caused by trauma, disease, aging, and stress.
Using mice, it investigates at the molecular level the basic principles of the mechanisms that protect neurons and promote their repair.
Noting that nerves are distributed not only in the brain but also in organs throughout the body, the lab also studies how nerves are involved in repair when organs are injured.
The lab was established in November 2024.
Key terms
- Motor neuron
- A neuron that sends movement commands to muscles. It can survive and regenerate even after axonal injury
- Axon
- A long projection extending from a neuron. It serves as the pathway for sending signals to other cells
- DINE
- A protease (metalloprotease) in the neuronal membrane whose expression increases when nerves are injured
NewsLab news
An undergraduate student won the Best Presentation Award at the Basic Medicine Seminar Presentation Meeting
Paper on the pathological mechanisms of amyotrophic lateral sclerosis (ALS) published in the journal Brain
A new lab has been launched
ResearchResearch themes
Neurons are vulnerable to damage from trauma, disease, aging, and stress, which can lead to degeneration and cell loss. The lab aims to clarify at the molecular level the basic principles of the various mechanisms that neurons activate in response to the emergency of damage, and to use this to advance the understanding of neuronal protection and repair.
*Illustrative imageHow neurons withstand damage
Motor neurons are exceptional neurons that can survive and regenerate even after axonal injury. Using this injury model, the lab investigates the response mechanisms that neurons need in order to withstand damage, aiming to elucidate the pathology of diseases such as ALS and Alzheimer's disease.
*Illustrative imageHow nerves promote organ repair
When organs and tissues are injured, the nerves distributed within them are also injured. Taking DINE, a molecule whose expression increases after nerve injury, as a starting point, the lab investigates the mechanisms that promote repair between injured nerves and tissue, and is also advancing research on neural circuits involved in chronic stress.
MembersFaculty
The lab's members consist of faculty members, technical staff, technical assistants, and undergraduate students.As of 2026
- ProfessorSumiko Kiryu-Seo-Seo
- Project LecturerKenichi Nagata
- LecturerSakiko Matsumoto
- Assistant ProfessorKoji Wakatsuki
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “The neuroscience imaging lab” Rosario Gulino / CC BY-SA 4.0 (cropped)
- How neurons withstand damage: “Neuron cluster” M. Oktar Guloglu / CC BY-SA 4.0 (cropped)
- How nerves promote organ repair: “Sciatic nerve immunofluorescence image after implantation of silicone tube” Valeriia Ustymenko / CC BY 4.0 (cropped)
- Related lab (分子細胞免疫学【免疫学】): “Immunology and Regenerative Medicine Research Laboratory - University of Calcutta - Ballygunge - Kolkata” Biswarup Ganguly / CC BY 3.0 (cropped)
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): “Observing Ocular Tissue under Laser Scanning Microscope ( )” National Eye Institute / CC BY 2.0 (cropped) - Related lab (統合生理学【生理学第二】): “Clinical thermometer 38.7” Menchi / CC BY-SA 3.0 (cropped)
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