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Cell Physiology (Physiology I) Lab
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The lab approaches the principles of how the brain forms and operates through auditory neural circuits.
AboutAbout the lab
Getting at the core principles of how the brain forms and operates
The Cell Physiology Lab aims to uncover the core principles of how the brain forms and operates, using auditory neural circuits as its subject.
In sound localization, the ability to tell which direction a sound comes from, one cue is the interaural time difference: the tiny difference in the time a sound reaches the left and right ears.
The neural circuit that detects this time difference is in the brainstem, and the lab investigates how that circuit is built and how it works.
The lab carries out multifaceted analyses using state-of-the-art research methods.
Key terms
- Sound localization
- The ability to tell which direction a sound comes from and perceive the surrounding space. It depends on hearing with two ears, left and right.
- Interaural time difference
- The difference in the time a sound reaches the left and right ears, depending on the direction of the sound source. It is only 1 millisecond at most.
- Oligodendrocyte
- A glial cell that adjusts the conduction velocity of neural activity depending on location.
NewsLab news
Lab members received the Excellent Poster Presentation Award at the Basic Medicine Seminar presentation session
A paper by Assistant Professor Ryo Egawa was published in eLife
An undergraduate student received the Junior Researcher Poster Award at the 48th Annual Meeting of the Japan Neuroscience Society
A paper by Assistant Professor Ryo Egawa was published in Front Cell Neuroscience
ResearchResearch themes
In the brain, an enormous number of cells form complex circuits. Using auditory neural circuits as its subject, this lab investigates how the individuality of neurons and functional local circuits arise.
*Illustrative imageNeuronal adaptation to frequency
The lab aims to clarify the molecular and cellular mechanisms by which auditory neurons optimize their function and structure according to the frequency they respond to within the tonotopic map.
*Illustrative imagePlasticity of the axon initial segment
The lab investigates the plasticity of the axon initial segment, which can powerfully control neural activity. This plasticity is attracting attention as a basis of diverse brain functions and disease states.
*Illustrative imagePrinciples determining the position of nodes of Ranvier
The lab aims to clarify how glial cells called oligodendrocytes finely tune the conduction velocity of neural activity depending on location.
*Illustrative imageFormation of precise axonal wiring
Using the auditory circuit, which achieves the ultimate temporal precision, as its subject, the lab aims to clarify the regulatory mechanisms by which axon branches are formed in a manner dependent on timing and location.
MembersFaculty
The Cell Physiology Lab's members are faculty, doctoral, master's, and undergraduate students, administrative assistants, and technical assistants.As of 2026
- ProfessorHiroshi Kuba
- Associate ProfessorHirokazu Sakamoto
- Assistant ProfessorRyo Egawa
- Assistant ProfessorRyota Fukaya
- Project Assistant ProfessorRyota Adachi
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Owl sound localization parallel processing in brain” Discclaimer / Public domain (cropped)
- Neuronal adaptation to frequency: “GFP Neurons” ManuelSchottdorf / CC BY-SA 4.0 (cropped)
- Plasticity of the axon initial segment: “Neuron (100x magnification)” Ns takes photos / CC BY 4.0 (cropped)
- Principles determining the position of nodes of Ranvier: “Nodes of Ranvier” Mgcaptainzanko / CC BY 4.0 (cropped)
- Formation of precise axonal wiring: “A Cortical Neuron In Isolation” Dchordpdx / CC BY 4.0 (cropped)
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