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Molecular and Cellular Immunology Lab
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The lab studies how the immune system works and how cancer escapes from it.
AboutAbout the lab
Uncovering the relationship between cancer and the immune system, starting from how immunity works
The Molecular and Cellular Immunology Lab studies the immune system and the diseases caused by its abnormalities, ranging from basic research to translational research.
The immune system not only eliminates non-self substances such as microorganisms, but also helps maintain the state of the body and is involved in the establishment of pregnancy.
In cancer, the immune system eliminates abnormal cells (immune surveillance), while cancer cells escape from the immune system (immune escape) and the disease progresses.
The lab aims to connect its research to an understanding of the path from immune surveillance to immune escape, one of the most important issues in immunology.
Key terms
- Immune escape
- When cancer cells acquire mechanisms to suppress immunity and escape elimination by the immune system
- T cell receptor
- A molecule on T cells that recognizes part of an antigen. Each cell expresses one type
- Immune checkpoint
- A molecule that appears when T cells are activated and negatively regulates T cell function. It suppresses excessive activation
- Regulatory T cell
- A cell that plays a central role in suppressing immunity. The transcription factor FOXP3 serves as its marker
ResearchResearch themes
The lab aims to understand the homeostasis maintained by the immune system and the various pathological conditions caused by immune abnormalities. Its work ranges from basic research to translational research using specimens from cancer patients.
*Illustrative imageT cell diversity and cancer immunotherapy
Focusing on the diversity of CD8-positive T cells that attack cancer cells, the lab aims to develop new cancer immunotherapies. In aged mice, which have low T cell receptor diversity, it uses drugs to control molecules involved in differentiation in the thymus and attempts to restore diversity.
*Illustrative imageCombination with immune checkpoint inhibitors
The lab searches for combination therapies that enhance the effect of anti-PD-1 antibodies. It examines candidate combination drugs in animal models and is developing a combination therapy with a virus-based agent, which is expected to become a new cancer treatment.
*Illustrative imageRegulation of transcription factors in immune cells
The lab studies new regulatory mechanisms of transcription factors such as FOXP3 in regulatory T cells and T-bet and Eomes in CD8-positive T cells. It purifies protein complexes using antibodies against the transcription factors and attempts to identify new proteins by mass spectrometry.
*Illustrative imageClinical research using specimens from cancer patients
In cooperation with the departments of internal medicine and surgery, the lab has built an environment in which blood and tumor tissue can be collected from cancer patients, and it compares the immune cells in each. It also analyzes changes in immune responses before and after antibody therapy, and the relationship between gut and oral bacteria and immune responses.
MembersFaculty
The members of the Molecular and Cellular Immunology Lab are a Professor, a Lecturer, and an Assistant Professor.
- ProfessorHiroyoshi Nishikawa
- LecturerSachiko Ito
- Assistant ProfessorKOCHIN Vitaly
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Immunology and Regenerative Medicine Research Laboratory - University of Calcutta - Ballygunge - Kolkata” Biswarup Ganguly / CC BY 3.0 (cropped)
- T cell diversity and cancer immunotherapy: “Healthy Human T Cell” NIAID/NIH / Public domain (cropped)
- Combination with immune checkpoint inhibitors: “Tislelizumab PB-1 7BXA” Fvasconcellos (talk · contribs) / Public domain (cropped)
- Regulation of transcription factors in immune cells: “Crystal Structure of the NC2-TBP-DNA Ternary Complex 1JFI” Kamada, K., Shu, F., Chen, H., Malik, S., Stelzer, G., Roeder, R.G., Meisterernst, M., Burley, S.K., New York SGX Research Center for Structural Genomics (NYSGXRC) / CC0 (cropped)
- Clinical research using specimens from cancer patients: “Doctor taking blood sample for COVID-19 rapid testing” Truyền Hình Pháp Luật / CC BY 3.0 (cropped)
- Related lab (Functional Histology Lab (Anatomy II)): “The neuroscience imaging lab” Rosario Gulino / CC BY-SA 4.0 (cropped)
- Related lab (Virology Lab): “Electron micrograph showing three Epstein-Barr virus (EBV) particles colorized pink” NIAID / Public domain (cropped)
- Related lab (Molecular Oncology (Cancer Cells) Lab): “Gel electrophoresis apparatus demonstration” Ajay Kumar Chaurasiya / CC BY-SA 4.0 (cropped)
- Related lab (Molecular Biology (Biochemistry I) Lab): “Smartphone colorimetry – 96-well microplate with serial dilutions of coloured solutions” Mdc-science / CC BY-SA 4.0 (cropped)
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