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Virology Lab
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The lab studies virology, investigating how viruses that cause disease in humans work.
AboutAbout the lab
Revealing at the molecular level how viruses cause disease
The Virology Lab studies viruses that cause disease in humans, such as herpesviruses and influenza virus.
The lab works to clarify how viruses cause disease and to develop methods for diagnosing, controlling, and treating viral diseases.
Viruses cause severe infectious diseases and can also cause cancers such as liver cancer and malignant lymphoma.
The lab is part of the Department of Microbiology and Immunology in the Graduate School of Medicine.
Key terms
- Epstein-Barr virus
- A type of herpesvirus. Most adults are infected, and it sometimes causes malignant lymphoma, nasopharyngeal cancer, and other diseases
- Chronic active EBV infection
- An intractable lymphoproliferative disease involving EBV
- Host factor
- A molecule of the infected side (the host) that a virus uses to replicate. Viruses cannot replicate on their own
ResearchResearch themes
The lab investigates at the molecular level how viruses replicate in host cells and lead to disease and cancer. The main subjects are herpesviruses such as Epstein-Barr virus (EBV) and RNA viruses such as influenza virus.
*Illustrative imageHow viruses cause cancer
EBV causes cancer and other intractable diseases in a very small number of people. By comprehensively examining the genes of patients and viruses with next-generation sequencing, the lab found that EBV associated with chronic active EBV infection lacks important genes.
*Illustrative imageHow viruses evade the immune system
Many viruses have mechanisms that suppress the immune responses of human cells. The lab investigates the various immune evasion mechanisms acquired by EBV in relation to nucleic acid sensor molecules and signal transduction.
*Illustrative imageSearching for host factors involved in viral infection
Viruses cannot replicate on their own and always need a host. Using a library of gene-knockout cells made with CRISPR/Cas9 (covering about 19,000 human genes), the lab searches for host factors required for infection by viruses such as herpes simplex virus.
*Illustrative imageEntry of influenza virus into cells
In international collaboration with overseas researchers, the lab studies host proteins that function when influenza virus enters cells. It is known that the virus uses ubiquitin chains to recruit the host protein HDAC6 and release its genomic RNA into the cytoplasm, and the lab aims to search for new antiviral drugs.
MembersFaculty
- ProfessorHiroshi Kimura
- Associate ProfessorYoshitaka Sato
- LecturerTakahiro Watanabe
- Project Associate ProfessorYasuyuki Miyake
- Assistant ProfessorAtsuko Sugimoto
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Electron micrograph showing three Epstein-Barr virus (EBV) particles colorized pink” NIAID / Public domain (cropped)
- How viruses cause cancer: “Blood film 01” CDC / Public domain (cropped)
- How viruses evade the immune system: “Scanning electron micrograph of a human H9 T cell infected with HIV virus particles” NIAID / CC BY 2.0 (cropped)
- Searching for host factors involved in viral infection: “6 and 12 wells cell culture plates-02” Lilly_M / CC BY-SA 3.0 (cropped)
- Entry of influenza virus into cells: “Influenza A Virus (H1N1)-1” NIH Image Gallery / Public domain (cropped)
- Related lab (Hematology and Oncology Lab): “FACS-toestel” Biol / Public domain (cropped)
- Related lab (Molecular and Cellular Immunology Lab): “Immunology and Regenerative Medicine Research Laboratory - University of Calcutta - Ballygunge - Kolkata” Biswarup Ganguly / CC BY 3.0 (cropped)
- Related lab (Cardiovascular Medicine Lab): “A cardiac catheterization procedure in the Naval Medical Center San Diego hospital’s cardiac catheterization laboratory” Navy Medicine / Public domain (cropped)
- Related lab (Molecular Biology (Biochemistry I) Lab): “Smartphone colorimetry – 96-well microplate with serial dilutions of coloured solutions” Mdc-science / CC BY-SA 4.0 (cropped)
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