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Molecular Oncology (Cancer Cells) Lab
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A lab that explores new cancer therapies based on the mechanisms of the genome and RNA.

AboutAbout the lab
Exploring cancer treatments through the mechanisms of the genome and RNA
The Molecular Oncology Lab aims to clarify the operating principles of the genome and RNA and, based on that understanding, to elucidate the mechanisms of cancer and discover new therapies.
The lab explores mechanisms of gene regulation and disease by integratively analyzing large-scale data made possible by advances in technologies such as next-generation sequencing, bioinformatics, and genome editing.
In April 2026, the lab moved to the Institute of Medical Science, the University of Tokyo (Division of Biochemistry and Integrative Cancer Research).
On the lab's website, it is presented under the name “Suzuki Lab.”
Key terms
- Super-enhancer
- A genomic region in which binding sites for cell-type-specific transcription factors are densely clustered
- Phase separation
- A phenomenon attracting attention as a mechanism for forming membraneless structures inside cells; it is involved in gene regulation and signal transduction
- Extrachromosomal circular DNA
- Circular DNA located outside the chromosomes; it has been widely reported in cancer cells and contains oncogenes and enhancers
NewsLab news
A review on biomolecular condensates and extrachromosomal DNA was published in Jpn J Clin Oncol
The lab moved to the Institute of Medical Science, the University of Tokyo
A paper on a genome editing technology targeting circular extrachromosomal DNA was published in Nucleic Acids Research
A paper was published in The Journal of Pathology
A paper was published in Oncogene
ResearchResearch themes
This lab aims to clarify in detail the operating principles of the genome and RNA and, based on that understanding, to uncover the mechanisms of cancer. It also aims to establish the basic concept of new precision medicine for cancer, a disease of the genome, along with the methods and technologies that make it possible.
*Illustrative imageSuper-enhancers and phase separation
Focusing on RNA, the lab investigates the function of super-enhancers. It explores the relationship between intracellular phase separation and genome and transcription regulation through data analysis and the development of new technologies, and is also advancing functional analysis using machine learning.
*Illustrative imageCancer therapy targeting extrachromosomal circular DNA
The lab focuses on extrachromosomal circular DNA (eccDNA), which is found in cancer cells but not in normal cells. It is developing transcription-targeted therapies with higher specificity that target this DNA.
*Illustrative imageTranscription biology from the perspective of RNA diversity
The lab studies the dynamics of transcription at enhancers and promoters from the perspectives of genome science and information science, aiming to understand the details of the transcription cycle. It explores new mechanisms of transcription regulation and extends this work to cancer research.
*Illustrative imageMultilayered omics and single-cell analysis
The lab adds single-cell analysis to the integrative analysis of large-scale data from next-generation sequencing. It is analyzing the pathology of various diseases, not only cancer.
MembersFaculty
The members of the Molecular Oncology Lab consist of faculty, doctoral, master's, and undergraduate students, international students, visiting researchers, technical assistants, and administrative assistants.As of 2026
- ProfessorHiroshi Suzuki
- LecturerKoichi Onoue
- Assistant ProfessorYutaka Watanabe
- Assistant ProfessorEri Koshi
- Assistant ProfessorYohei Sugimoto
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Gel electrophoresis apparatus demonstration” Ajay Kumar Chaurasiya / CC BY-SA 4.0 (cropped)
- Super-enhancers and phase separation: “Super-enhancer” MethylC5 / CC0 (cropped)
- Cancer therapy targeting extrachromosomal circular DNA: “Plasmid (NIH BioArt )” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Transcription biology from the perspective of RNA diversity: “RNA Polymerase III open complex - Transcription factor TFIIIB component B" (2) - 6F40” Vorlaender, M.K., Khatter, H., Wetzel, R., Hagen, W.J.H., Mueller, C.W. / CC0 (cropped)
- Multilayered omics and single-cell analysis: “DNA Nanoball sequencing flow cell” Suspencewl / CC0 (cropped)
- Related lab (Cell Biology / Ultrastructural Morphology (Anatomy III) Lab): “Biology laboratory” Eduardo from Bloomington, IN / CC BY-SA 2.0 (cropped)
- Related lab (Tumor Biology (Molecular Pathology) Lab): “Laboratory (2)” Linda Bartlett (Photographer) / Public domain (cropped)
- Related lab (Data-Driven Biology Lab): “Fluorescence.microscope3” Bioguy10 / CC0 (cropped)
- Related lab (Molecular and Cellular Immunology Lab): “Immunology and Regenerative Medicine Research Laboratory - University of Calcutta - Ballygunge - Kolkata” Biswarup Ganguly / CC BY 3.0 (cropped)
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