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Molecular and Cellular Pharmacology (Pharmacology) Lab
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A lab studying how synapses work and how that process breaks down.
AboutAbout the lab
Toward uncovering the basic principles of synaptic transmission
The Fukata Lab, part of the Department of Neural Information Pharmacology, studies the mechanisms that regulate the function of synapses, the basic unit of higher brain function, and how those mechanisms break down in brain diseases.
The lab focuses on the regulatory mechanisms of AMPA-type glutamate receptors, which are thought to form the molecular basis of memory and learning.
The property by which the efficiency of synaptic transmission changes in response to external stimuli (synaptic plasticity) is thought to be the molecular basis of memory and learning.
The lab combines biochemistry, molecular and cell biology, histology, electrophysiology, and mouse genetics in its research.
Key terms
- AMPA-type glutamate receptor
- An ion channel responsible for the main excitatory neurotransmission in the brain. Changes in its number and function are linked to the efficiency of synaptic transmission
- Synaptic plasticity
- The flexible change, depending on input stimuli, in the efficiency of information transmission at synapses
- Palmitoylation
- A modification in which palmitic acid is attached to a protein, regulating its localization and function. It is a reversible reaction in which the modification can be added and removed
NewsLab news
A student won the Best Presentation Award at the 35th Basic Medicine Seminar Research Presentation Meeting
Variants of both LGI1 and ADAM23 found in patients for the first time, in an international collaborative study
A review marking the 10th anniversary of the discovery of synaptic nanodomains was published in J Neurosci, co-authored with overseas researchers
The Fukata Lab moved from the National Institute for Physiological Sciences to the Department of Neural Information Pharmacology, Nagoya University Graduate School of Medicine
ResearchResearch themes
The Fukata Lab investigates the regulatory mechanisms of AMPA-type glutamate receptors, which are thought to be the molecular basis of memory and learning, as mechanisms that modulate synaptic transmission. Currently, the lab focuses mainly on palmitoylation, a lipid modification in which palmitic acid is attached to proteins, and on LGI1 and ADAM22, a ligand and receptor associated with epilepsy.
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MembersFaculty
The lab's members consist of faculty, postdoctoral researchers, doctoral and master's students, and technical assistants.As of 2026
- ProfessorMasaki Fukata
- Associate ProfessorYuko Fukata
- LecturerNorihiko Yokoi
- Assistant ProfessorYuri Miyazaki
- Associate ProfessorKeisuke Kuroda
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Microscope à fluorescence (Ifremer )” Olivier Dugornay / CC BY 4.0 (cropped)
- Building synapses through palmitoylation: “Protein DLG4 PDB 1be9” Emw / CC BY-SA 3.0 (cropped)
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