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Nanobiosensing Lab
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A lab that builds its own microscopes to see what could not be seen before.
AboutAbout the lab
Building microscopes to see the invisible.
Nano-Bio Measurement Lab develops new measurement technologies to uncover what has not been understood until now.
The lab independently develops scanning probe microscopes that use extremely thin glass tubes and other tools to observe cells and materials in liquid at the nanoscale.
Because the lab builds everything itself, from instrument hardware to measurement and analysis software, students also learn skills such as producing design drawings and building electronic circuits.
The lab visualizes phenomena that were previously invisible, such as the growth of nerve cells and the workings of catalyst materials and rechargeable batteries.
Key terms
- Scanning probe microscope
- A microscope that moves a fine probe across the surface of a sample, as if tracing it, to turn the surface's shape and properties into an image.
- SICM
- Scanning ion conductance microscopy. It measures the shape of cells in liquid using the ion current flowing through a thin glass tube.
- Catalyst
- A substance that makes a chemical reaction occur more easily without itself being changed.
NewsLab news
A paper on joint research with Tohoku University (nanosheets) was published in APL Energy
A paper on joint research with Tokyo Metropolitan University (Janus nanosheets) was published in ACS Nano
A paper on copper ion sensing was published in Analytical Chemistry
Student-led research on layer-by-layer (LbL) films was published in Electrochimica Acta
A paper on joint research was published in Electroanalysis
ResearchResearch themes
The lab conducts research that clarifies what was previously unknown by developing new technologies. It has independently developed scanning probe microscopes that observe cells and materials in liquid at the nanoscale, and it works on both life science and materials science.
*Illustrative imageSeeing Movement on the Cell Surface at the Nanoscale
The lab has developed scanning ion conductance microscopy (SICM), which uses a thin glass tube, to visualize changes on the cell surface that optical microscopes cannot see. It aims to clarify how nanoscale substances such as viruses are taken up into cells.
*Illustrative imageBiosensors That Capture Subtle Cell Responses
To measure on the spot the chemicals that a single cell consumes and releases, the lab develops biosensors using microelectrodes and scanning electrochemical microscopy (SECM). It also uses nanopipettes to stimulate cells locally and to introduce reagents into cells.
*Illustrative imageImaging How Catalyst Materials Work
Using scanning electrochemical cell microscopy (SECCM), which the lab developed independently, the lab captures catalytic activity at the nanoscale. For MoS2, which is attracting attention as a catalyst for producing hydrogen, it visualized how the ease of reaction differs from place to place. The technique can also be used to evaluate energy storage materials and corrosion.
MembersFaculty
Nano-Bio Measurement Lab consists of faculty members, doctoral, master's, and undergraduate students, postdoctoral researchers, and technical assistants.
- ProfessorYasufumi Takahashi
- LecturerHiroki Ida
- Project Associate ProfessorHajime Sakurai
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Atomic force microscope by Zureks” Zureks / CC BY-SA 3.0 (cropped)
- Seeing Movement on the Cell Surface at the Nanoscale: “Cell membrane with proteins visualized by AFM” Nucturra / CC0 (cropped)
- Biosensors That Capture Subtle Cell Responses: “Pyramidal hippocampal neuron with fake microelectrode” Laurens R. Krol / CC BY-SA 4.0 (cropped)
- Imaging How Catalyst Materials Work: “Platinum nanoparticles” PieroSpeleo / CC BY-SA 4.0 (cropped)
- Related lab (ナノ電子デバイス研究グループ): “Hukseflux flexible heat flux sensor FHF04 with incorporated temperature sensor” Hukseflux TS / CC BY-SA 4.0 (cropped)
- Related lab (プラズマナノプロセス科学研究グループ): “Plasma Pencil” Entropi5 / CC BY-SA 3.0 (cropped)
- Related lab (制御システム研究グループ): “Chemical Genomics Robot” Maggie Bartlett, National Human Genome Research Institute / Public domain (cropped)
- Related lab (光エレクトロニクス研究グループ): “Laser experiment - Photonics Laboratory - Physics Department - Ateneo de Manila University” Physics Department Ateneo de Manila University / CC BY 2.0 (cropped)
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