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Chiba Lab
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A biogerontology lab that unravels the mechanisms of aging and develops ways to prevent it.

AboutAbout the lab
Contributing to healthy longevity through basic medical science.
The Chiba Lab studies how aging works and develops ways to prevent it.
This field, which approaches aging with the methods of molecular biology and experimental pathology, is also known as biogerontology.
Aging is one of the major risk factors for cancer, lifestyle-related diseases, and neurodegenerative diseases such as Alzheimer's disease.
The lab therefore aims to lead to the development of drugs, Kampo and herbal medicines, and functional foods that slow aging.
Key terms
- Biogerontology
- A research field that investigates why living things age, from the perspective of molecular and cellular mechanisms
- Calorie restriction
- Reducing the amount of food eaten while keeping nutrition balanced. It extends lifespan in many organisms
- Progeria
- A disease in which a congenital genetic abnormality causes aging to progress faster than one's actual age
ResearchResearch themes
The lab aims to elucidate the mechanisms of aging and apply them to develop drugs, functional foods, and more, contributing to people's health and well-being. Using model organisms, genetically modified mice, and cultured cells, it searches for the mechanisms that determine lifespan and for substances that regulate them.
*Illustrative imageMechanisms that regulate lifespan
Restricting calorie intake extends lifespan in many organisms. To explore the aging-control mechanisms shared across species, the lab studies mice in which genes involved in feeding and metabolism have been disrupted.
*Illustrative imageSearching for anti-aging substances
The lab has developed a method to search for substances that produce the same anti-aging effects as calorie restriction without restricting food intake. Using this method, it is advancing research and development of drugs that improve age-related diseases, as well as anti-aging supplements.
*Illustrative imageDNA damage and progeria
Radiation, ultraviolet light, and chemicals damage DNA. Abnormalities in proteins involved in the mechanisms that repair this damage cause progeria, in which aging progresses prematurely. The lab studies the molecular mechanisms behind this.
MembersFaculty
- ProfessorTakuya Chiba
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Sand clock Enschede” Gianluca Miscione / CC BY-SA 4.0 (cropped)
- Mechanisms that regulate lifespan: “Black-mouse-trio-in-cage-2” Commissioned by Understanding Animal Research / CC BY-SA 4.0 (cropped)
- Searching for anti-aging substances: “96 well plate” J.N. Eskra / CC BY-SA 4.0 (cropped)
- DNA damage and progeria: “DNA Helix CPK” Ude / Public domain (cropped)
- Related lab (神山研究室): “Human Brain Organoid” Nreis1 / CC BY 4.0 (cropped)
- Related lab (榊原研究室): “Pyramidal hippocampal neuron 40x” MethoxyRoxy / CC BY-SA 2.5 (cropped)
- Related lab (加藤一聖研究室): “Menthol Crystals close up” Debeo Morium / CC BY-SA 3.0 (cropped)
- Related lab (原太一研究室): “Garlic bulbs and cloves” Ivar Leidus / CC BY-SA 4.0 (cropped)
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