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Kohyama Lab
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A stem cell biology lab that explores how neurons arise from stem cells.
AboutAbout the lab
From stem cells to how the brain forms.
Kohyama Lab studies how neurons are generated, using the functions of stem cells as a clue.
Its fields are stem cell biology and regenerative medicine, and it uses methods from physiology, neuroscience, and molecular biology.
The lab generates neural cells from human iPS cells and investigates how the function of genes determines cell fate.
These findings are expected to provide clues for understanding the mechanisms of neurodevelopmental disorders and brain tumors.
Key terms
- Stem cell
- A cell that can make copies of itself while also becoming many different types of cells
- iPS cell
- A cell, such as a skin cell, that has had genes introduced to return it to a state in which it can become various cell types of the body
- Organoid
- A three-dimensional cluster of cells grown from stem cells that recreates part of an organ in miniature
NewsLab news
View More ↗ResearchResearch themes
The lab aims to clarify, at the molecular level, how stem cells change into neural cells. Using neural cells and organoids made from human iPS cells, it investigates the mechanisms that control how genes function.
*Illustrative imageDetermining Neural Progenitor Cells
Inside cells, proteins sometimes gather like liquid droplets to form sites where they function. The lab has clarified how such assemblies determine the properties of neural progenitor cells.
*Illustrative imageA Tiny Brain in a Dish
Brain organoids, grown in three dimensions from human iPS cells, are a new tool for studying brain development and disease. The lab introduces the potential of this technology and how it can best be used, with psychiatry researchers also in mind.
MembersFaculty
- ProfessorJun Kohyama
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Human Brain Organoid” Nreis1 / CC BY 4.0 (cropped)
- Determining Neural Progenitor Cells: “Microglia and neurons” GerryShaw / CC BY-SA 3.0 (cropped)
- A Tiny Brain in a Dish: “Organoïde intestinal” Paul Barreau / CC BY-SA 4.0 (cropped)
- Related lab (Kato Lab): “Menthol Crystals close up” Debeo Morium / CC BY-SA 3.0 (cropped)
- Related lab (Sakakibara Lab): “Pyramidal hippocampal neuron 40x” MethoxyRoxy / CC BY-SA 2.5 (cropped)
- Related lab (Hara Lab): “Garlic bulbs and cloves” Ivar Leidus / CC BY-SA 4.0 (cropped)
- Related lab (Chiba Lab): “Sand clock Enschede” Gianluca Miscione / CC BY-SA 4.0 (cropped)
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