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Sakakibara Lab
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A molecular neuroscience lab that explores, at the molecular level, how the brain is built and protected.
AboutAbout the lab
Uncovering the microscopic mechanisms that keep the brain working.
Sakakibara Lab studies, at the molecular level, how the brain is built and protected.
Building a mammalian brain requires strict control of the division and differentiation of neural stem cells.
The lab therefore searches for new molecules that regulate neural stem cells and investigates how proteins are regulated after they are made.
The genes it has found act beyond the brain: in a collaboration with another university, they were also shown to support lipid metabolism in the liver.
Key terms
- Neural stem cell
- A cell that divides to leave copies of itself while also being able to become neurons and glial cells
- Differentiation
- The process by which a progenitor cell changes its properties to become a cell with a specific role
- Endoplasmic reticulum
- A sac-like structure inside cells that folds proteins and stores calcium
NewsLab news
View More ↗ResearchResearch themes
The lab finds new molecules that control the division and differentiation of neural stem cells and confirms their function at the level of the whole organism. It also investigates how modifications that proteins undergo after they are made, and the function of the endoplasmic reticulum inside cells, support the health of the brain and body.
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MembersFaculty
- ProfessorShinichi Sakakibara
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Pyramidal hippocampal neuron 40x” MethoxyRoxy / CC BY-SA 2.5 (cropped)
- Endoplasmic Reticulum Stress and Liver Disease: “Hepatocyte (NIH BioArt 202)” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Related lab (神山研究室): “Human Brain Organoid” Nreis1 / CC BY 4.0 (cropped)
- Related lab (加藤一聖研究室): “Menthol Crystals close up” Debeo Morium / CC BY-SA 3.0 (cropped)
- Related lab (大須研究室): “The Human Connectome” Andreashorn / CC BY-SA 4.0 (cropped)
- Related lab (千葉研究室): “Sand clock Enschede” Gianluca Miscione / CC BY-SA 4.0 (cropped)
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