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Takeoka Lab
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The lab builds nanoscale membranes and particles from assembled molecules and puts them to use in medicine.
AboutAbout the lab
Turning molecular assemblies into tools for medicine.
The Takeoka Lab studies structures formed by the assembly of lipids, biomedical polymers, proteins, nucleic acids, and other molecules, and applies them to medicine.
The lab makes nanosheets, which are free-standing films only nanometers thick, and liposomes, which are lipid vesicles, and examines their properties.
Applications are expanding to drug carriers, devices attached to the body to measure biological signals, and particles that act as substitutes for platelets.
The lab also develops new fluorescent probes for observing phenomena inside cells.
Key terms
- Nanosheet
- A thin polymer film only nanometers thick that can hold its shape on its own
- Liposome
- A small vesicle formed by a lipid bilayer that can hold drugs and other substances inside
- Fluorescent probe
- A molecule that glows in response to a target molecule or environment, making conditions inside cells visible
NewsLab news
Paper on controlled release of hydrophobic molecules from polymer composite thin films published in Macromolecular Chemistry and Physics
A student won an Excellent Poster Award at the 73rd Symposium on Macromolecules
A doctoral student won a Best Poster Presentation Award at the World Biomaterials Congress
Paper on the stability and cytotoxicity of self-doped PEDOT nanosheets published in ACS Applied Polymer Materials
ResearchResearch themes
The Takeoka Lab studies molecular assemblies and structures formed by amphiphilic molecules, biomedical polymers, proteins, nucleic acids, and other molecules. Its aim is to apply these in medicine as drug carriers and nanodevices.
*Illustrative imageNanosheet Group
This research evaluates the physical properties of free-standing polymer nanosheets and applies them to medicine. The lab is developing an electronic nano-bandage that reveals muscle activity simply by being applied to the skin, a flexible neural electrode that can record action potentials from brain tissue, and a sheet loaded with antibacterial microcrystals to treat infected burn wounds.
*Illustrative imageBioimaging Group
The lab develops new fluorescent probes that visualize various physiological phenomena inside cells. It is making a small-molecule thermometer that accumulates in mitochondria simply by being added to living cells and measures their temperature by fluorescence, as well as probes that bind to target molecules inside cells so that their movements can be tracked.
*Illustrative imageNanomedicine Group (Liposomes)
Using liposomes made from amino acid-based lipids, the lab develops more efficient drug carriers. It found that the way siRNA and lipids assemble greatly changes the efficiency of delivery into cells, and it has also explored using a dispersion of oxygen micro/nanobubbles as a liquid with a high oxygen concentration for total liquid ventilation.
*Illustrative imageNanomedicine Group (Artificial Platelets)
The lab develops nanoparticles that gather at bleeding sites and promote platelet aggregation. These are phospholipid vesicles with peptides bound to their surface and a substance that triggers platelet aggregation enclosed inside. They have been confirmed to gather at sites of vascular injury and shorten bleeding time. The lab is now evaluating their efficacy and conducting safety tests, aiming for clinical application.
MembersFaculty
The Takeoka Lab's members are faculty, staff, visiting researchers, and students in the doctoral, master's, and undergraduate programs.As of 2026
- ProfessorShinji Takeoka
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Lipid Islands on Soap Bubble” KarlGaff / CC BY 4.0 (cropped)
- Nanosheet Group: “Interference Colors from a Thin polymer Film” Tafaltens / CC BY-SA 3.0 (cropped)
- Bioimaging Group: “MEF cell mitochondria 2” Institute of Molecular Medicine I, University of Düsseldorf / CC BY 4.0 (cropped)
- Nanomedicine Group (Liposomes): “Phosphatidylcholine liposomes stained with acridine orange” ArkhipovSergey / CC BY-SA 4.0 (cropped)
- Nanomedicine Group (Artificial Platelets): “WBC (neutrophil) at centre, numerous erythrocytes and platelets (dot like bodies) in Wright's stained peripheral blood smear (PBS) microscopy” Ajay Kumar Chaurasiya / CC BY-SA 4.0 (cropped)
- Related lab (武田研究室): “3D printed Hydrogel Scaffold” Habannn / CC0 (cropped)
- Related lab (朝日研究室): “Ibuprofen-crystals-polarized-light-microscopy” Janeklass / CC BY 4.0 (cropped)
- Related lab (井上研究室): “Erratic Flight of Fireflies” Bernd Thaller / CC BY 2.0 (cropped)
- Related lab (大島研究室): “Mouse Brain Coronal (NIH BioArt )” NIAID Ryan Kissinger / Public domain (cropped)
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