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Ohshima Lab
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A lab that explains how the brain is formed through the action of genes.
AboutAbout the lab
Uncovering the molecular mechanisms of brain development
The Ohshima Lab studies how the brain takes shape and comes to function, from the action of genes and proteins.
Using mice and zebrafish, the lab examines at the level of the whole organism what roles genes play during brain development.
The central theme is the mechanism by which neurons are generated, migrate to the correct locations, and connect with the correct partners to form neural circuits.
The lab aims to connect this basic research to the development of treatments for neurological diseases and to neural regenerative medicine.
Key terms
- Neural circuit
- A network formed by neurons connecting with one another to exchange information
- Neural stem cell
- A cell that can divide to produce copies of itself while also being able to turn into neurons
- Genetically modified mouse
- A mouse in which a specific gene has been disrupted or rewritten, used to study the function of that gene
NewsLab news
Paper accepted showing that suppressing CRMP2 phosphorylation reduces α-synuclein accumulation
A doctoral student received an Outstanding Poster Award at the Advanced Animal Model Support Platform results meeting
Paper accepted on gene expression in the hippocampus of Alzheimer's disease model mice
Paper on sex differences in adult brain neurogenesis published in Biology of Sex Differences
Paper co-authored by doctoral and master's students published in Nature
ResearchResearch themes
The Ohshima Lab aims to elucidate the molecular mechanisms of how neurons are generated, how cells migrate, how neural circuits form, and how function emerges. Using mice and zebrafish, the lab analyzes gene function during brain development at the level of the whole organism.
*Illustrative imageNeuronal migration and morphogenesis
The lab investigates the molecular mechanisms by which neurons migrate to the correct positions, differentiate, extend axons and dendrites, and connect with the correct partners. It focuses on Cdk5 and p35, which act in this process, and their substrate CRMP2, and analyzes mice and zebrafish in which these genes are knocked out.
*Illustrative imageMechanisms of memory, learning, and emotion
Cdk5 and p35 have been reported to phosphorylate various proteins involved in synaptic plasticity at the junctions between neurons. Using mice in which these genes are modified, the lab examines their involvement in higher-order cerebral functions such as memory, learning, and emotion, focusing on phosphorylation signaling.
*Illustrative imageNeural stem cells in the adult fish brain
In the adult brains of teleost fish such as zebrafish, neural stem cells are distributed across various regions and continually supply new neurons throughout life. Focusing on neural stem cells in the optic tectum, the target of optic nerve projections, the lab analyzes their proliferation and differentiation, aiming to clarify the general principles by which neural stem cells are maintained and differentiate.
*Illustrative imagePathology of neurological and psychiatric disorders
Using the neuronal degeneration and loss seen in Cdk5-deficient models as a clue, the lab attempts to elucidate the pathology of neurodegenerative diseases. Research also uses Alzheimer's disease model mice, a drug-induced Parkinson's disease model, and a spinal cord injury model.
MembersFaculty
The members of the Ohshima Lab consist of faculty members, visiting faculty members, researchers, and doctoral, master's, and undergraduate students.As of 2026
- ProfessorToshio Ohshima
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Mouse Brain Coronal (NIH BioArt )” NIAID Ryan Kissinger / Public domain (cropped)
- Neuronal migration and morphogenesis: “Hippocampal Neurons, stained” Ns takes photos / CC BY 4.0 (cropped)
- Mechanisms of memory, learning, and emotion: “White lab mice near” Pogrebnoj-Alexandroff / CC BY-SA 3.0 (cropped)
- Neural stem cells in the adult fish brain: “Leopard danio (cropped)” Roundish / CC0 (cropped)
- Pathology of neurological and psychiatric disorders: “Astrocytes surrounding amyloid plaques III” Pics56 / CC BY-SA 4.0 (cropped)
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