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Bioorganic Chemistry (Kuramochi Lab)
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A lab that makes its own compounds to uncover the mechanisms of life.
AboutAbout the lab
Using chemistry to unravel life phenomena
The Kuramochi Lab uses compounds it synthesizes itself as tools, aiming to elucidate biological phenomena at the molecular level.
Within a single lab, it takes on a broad range of research spanning chemistry, biology, physics, and the boundary areas between them.
Starting mainly from biologically active compounds, the lab carries out an integrated line of research, from synthesis and isolation to evaluation of activity and function, analysis of mechanism of action, and molecular design.
The lab was established in April 2016.
Key terms
- Chemical biology
- A field that elucidates biological phenomena through chemical methods. Compounds synthesized by the researchers themselves are used as tools to investigate life processes.
- Natural products
- A general term for naturally occurring organic compounds with biological activity. This lab handles them end to end, from chemical synthesis to analysis of their action.
- Affinity beads
- A tool for efficiently recovering proteins that bind to drugs. They are being developed in this lab.
NewsLab news
A student won the Outstanding Student Presentation Award at the 51st Annual Meeting of the Pesticide Science Society of Japan
A student won the Excellent Poster Award at the 39th Pesticide Design Research Meeting
A student's paper won the 2024 AATEX Outstanding Paper Award
A student won the Outstanding Presentation Award (oral presentation) at the 2024 Kanto Branch Meeting of the Japan Society for Bioscience, Biotechnology, and Agrochemistry
ResearchResearch themes
Chemical biology, which elucidates biological phenomena through chemical methods, is developing rapidly around the world. In this lab, compounds synthesized by the lab members themselves are used as tools to investigate biological phenomena, with the aim of clarifying life processes at the molecular level.
*Illustrative imageFrom natural product synthesis to analysis of action
For biologically active naturally occurring organic compounds, the lab conducts research as one continuous line, from chemical synthesis to analysis of their mode of action and function. It aims to develop drugs, agrochemicals, and diagnostic agents using natural products as lead compounds.
*Illustrative imageRecovering proteins that bind to drugs
Many drugs act by binding to specific proteins. By chemically modifying the surface of affinity beads, which recover binding proteins, through original molecular design, the lab aims to develop beads with higher performance.
*Illustrative imageCancer-related ubiquitin ligases
The lab focuses on the cancer-related ubiquitin ligases collectively known as IAPs, and studies methods that use their ubiquitination activity to induce ubiquitination of arbitrary proteins. It also aims to create new anticancer drugs that target IAPs.
*Illustrative imagePrevention, treatment, and diagnosis of rare diseases
Rare diseases, which affect very few patients, lag behind in basic research on prevention, treatment, and diagnosis. Aiming to enable early diagnosis and early treatment and to expand treatment options, the lab has begun research on adrenal cancer and alkaptonuria.
MembersFaculty
The Kuramochi Lab consists of a Professor, a Contract Special Lecturer, and doctoral, master's, and undergraduate students.As of 2026
- ProfessorKoji Kuramochi
- Contract Special LecturerYuki Furuyama
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Lionel-Porter Biocraft Biology Lab - DPLA - 0aee6b8d573cd6c84690d2ebb4449d32 (page 2)” Porter Chemical Company; Lionel Corporation / Public domain (cropped)
- From natural product synthesis to analysis of action: “Hibiscus medicinal plant” Prathvi Acharya / CC BY-SA 4.0 (cropped)
- Recovering proteins that bind to drugs: “GE Healthcare Akta Avant 25 FPLC system” Mjeltsch / CC BY-SA 4.0 (cropped)
- Cancer-related ubiquitin ligases: “Killer T cells surround a cancer cell” The National Institutes of Health / Public domain (cropped)
- Prevention, treatment, and diagnosis of rare diseases: “Five pharmaceutical capsules of various sizes” Omar abdallah al-qruoty / CC BY-SA 3.0 (cropped)
- Related lab (タンパク質科学
（中島 研究室） ): “Crystallized sugar, multiple crystals and a single crystal grown from seed” Zaereth / CC BY-SA 4.0 (cropped) - Related lab (応用生物化学
（古屋 研究室） ): “Enzymes -- Smart-Servier” Laboratoires Servier / CC BY-SA 3.0 (cropped) - Related lab (がん細胞生物学
（定家 研究室） ): “Telomeres” AJC1 / CC BY-SA 4.0 (cropped)
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