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Lipid Biology (Nakamura) Lab
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A lab that explores skin aging and disease through the roles of lipids in the cell membrane.
AboutAbout the lab
Reading skin and disease through cell membrane lipids
The Lipid Biology (Nakamura) Lab studies the phospholipids that make up cell membranes and the enzymes that metabolize them.
Through basic medical and biological research, the lab aims to produce results that can contribute to medicine.
Its subjects include skin aging, organ fibrosis and the malignant progression of cancer, and skin diseases accompanied by abnormal skin barrier function.
On the lab's website it is presented as the “Nakamura Lab,” and it was founded in 2019.
Key terms
- Phospholipid
- A lipid that makes up cell membranes. The amount of lipids is controlled by various lipid-metabolizing enzymes
- Epithelial cell
- A cell that covers the surface of the body and the inner surfaces of organs
- Fibroblast
- A cell in the dermis that produces collagen and other components and maintains the firmness and elasticity of the skin
NewsLab news
A master's student received the Student Excellent Presentation Award at the Annual Meeting of the Japan Society for Biomedical Gerontology
A master's student received the Outstanding Poster Presentation Award at the Kanto Branch Meeting of the Japanese Biochemical Society
Assistant Professor Kaori Kanemaru received the Encouragement Award of the Japan Society for Biomedical Gerontology for fiscal 2024
A paper on atopic dermatitis was published in Biochem Biophys Res Commun.
ResearchResearch themes
Lipids are substances that serve as components of biological membranes, energy stores, signaling factors, and biological barriers, and their amounts are controlled by various lipid-metabolizing enzymes. Focusing on phospholipids in biological membranes, the lab aims to clarify their biological importance and to understand the pathology of disease.
*Illustrative imageMechanisms and Control of Skin Aging
Age-related decline in the function of epidermal stem cells and aging of fibroblasts in the dermis are involved in skin aging. Focusing on how cell membrane phospholipids function in both cell types, the lab aims to clarify the mechanisms of aging and to control it.
*Illustrative image“Epithelial Cell Identity” and Fibrosis and Cancer
The loss of “epithelial cell identity” by epithelial cells is involved in organ fibrosis and in cancer invasion and metastasis. Having found that cell membrane phospholipids are important for maintaining and determining this identity, the lab aims to suppress fibrosis and the malignant progression of cancer by adjusting phospholipid levels.
*Illustrative imageSkin Barrier Abnormalities and Phospholipid-Metabolizing Enzymes
The barrier function of the skin is carried out by the epidermis, its outermost layer. The lab has shown that a phospholipid-metabolizing enzyme plays an important role in forming the epidermal barrier, and is investigating the link between this enzyme and skin diseases accompanied by barrier abnormalities.
MembersFaculty
The members of the Lipid Biology (Nakamura) Lab are faculty members, master's and undergraduate students, research assistants, and secretaries.As of 2026
- ProfessorYoshikazu Nakamura
- LecturerKaori Kanemaru
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Skin cancer cells from a mouse show how cells attach at contact points” National Institutes of Health (NIH) / Public domain (cropped)
- Mechanisms and Control of Skin Aging: “Young and old skin” Jorge Royan AND Wilfredor / CC BY-SA 3.0 (cropped)
- “Epithelial Cell Identity” and Fibrosis and Cancer: “COVID-induced Lung Fibrosis with fibrin deposits (red) associated with human lung epithelial cells infected with SARS-CoV-2” NIAID / CC BY 2.0 (cropped)
- Skin Barrier Abnormalities and Phospholipid-Metabolizing Enzymes: “The surface of highly curved lipid bilayer” Semen Yesylevskyy / CC BY 4.0 (cropped)
- Related lab (がん細胞生物学
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（古屋 研究室） ): “Enzymes -- Smart-Servier” Laboratoires Servier / CC BY-SA 3.0 (cropped)
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