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Kano Lab
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A lab that designs cells by combining cell engineering with mathematical analysis.
AboutAbout the lab
Designing cells through cell engineering and mathematical analysis
The Kano Lab aims to establish "cell editing engineering," a field that designs and edits cells.
The lab pursues interdisciplinary research that combines cell engineering experiments with bioinformatics and mathematical analysis.
As its foundation, the lab has developed two technologies: resealed cell technology and covariation network analysis.
The lab aims to put its results to use in society, not only in basic life science but also as technologies that support drug discovery and cell-based medicines.
Key terms
- Resealed cells
- Cells whose membrane is temporarily opened to let molecules in, and then sealed again
- Covariation network
- A network diagram showing the strength of relationships, obtained by examining how the changes of many proteins move together
- Immunofluorescence
- A method that uses antibodies tagged with fluorescent labels to see where, and how much, of a target protein is present in a cell
NewsLab news
Paper on single-cell covariation network analysis published in Commun. Biol.
Target molecule of a ferroptosis inducer identified; published in Commun. Biol.
Project Assistant Professor Kunishige receives the Institute of Science Tokyo Excellent Open Innovator Merit Award
ResearchResearch themes
By speeding up the cycle of designing and editing cells and evaluating the results, the lab aims to create cells with new functions, as well as cells in which disease states have been improved. As the foundation for this, it is developing two technologies: resealed cell technology and covariation network analysis.
*Illustrative imageResealed cell technology
A technology that temporarily opens pores in the cell membrane using agents such as biological toxins, in order to introduce various molecules into cells. It can also be used to introduce the entire cytoplasm of diseased cells into healthy cells, creating disease model cells.
*Illustrative imageCovariation network analysis
Stimulated cells are stained by immunofluorescence, and changes in protein amounts and in their localization within cells are measured from large numbers of images. How closely these changes move together over time is then visualized as a network of connections among proteins.
MembersFaculty
The members of the Kano Lab consist of faculty, technical staff, researchers from other institutions, and doctoral, master's, and undergraduate students.As of 2026
- ProfessorFumi KanoPublications ↗
- Assistant ProfessorRina KunishigePublications ↗
- Project ProfessorMasayuki MurataPublications ↗
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Osteosarcoma cells stained for actin, microtubules, and nuclei” Howard Vindin / CC BY 4.0 (cropped)
- Resealed cell technology: “AlphaHemolysin membrane heptamer 7AHL sideVw” Jane Richardson (Dcrjsr) / CC BY 3.0 (cropped)
- Covariation network analysis: “Human interactome” Keiono / CC BY-SA 3.0 (cropped)
- Related lab (関根研究室): “Multicolor fluorescence image of living HeLa cells” 8x57is / CC BY-SA 4.0 (cropped)
- Related lab (神谷研究室): “Fluorescence rainbow” Maxim Bilovitskiy / CC BY-SA 4.0 (cropped)
- Related lab (北口研究室): “Crystal Jelly ("Aequorea Victoria"), Monterey Bay Aquarium, Monterey, California, USA” Jim G from Silicon Valley, CA, USA / CC BY 2.0 (cropped)
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