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Mori Lab
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The lab studies glycans and lipids on the cell surface to create useful materials.
AboutAbout the lab
Pursuing what can be understood and what can be made.
The Mori Lab studies the roles that glycans and lipids on the cell surface play in living organisms.
At the same time, based on the findings obtained, it aims to create highly functional materials that are useful as biomaterials.
Using a quartz crystal microbalance, it tracks molecular binding and enzyme reactions as changes in mass.
The lab pursues its research from two sides: "what can be understood" and "what can be made."
Key terms
- Cell surface
- The outermost membrane of a cell and its surface. Glycans and lipids are arranged there, and it serves as the gateway for exchange with the outside.
- Glycan
- A chain of many sugars linked together. Glycans grow out from the cell surface and act as markers that let cells recognize each other.
- Quartz crystal microbalance (QCM)
- A thin plate of quartz that vibrates at a fixed rate when a voltage is applied. When something attaches to its surface, the vibration frequency drops, which shows how much has attached.
ResearchResearch themes
Using a quartz crystal microbalance and an atomic force microscope, the lab measures molecular recognition and enzymatic reactions occurring on DNA, glycans, and proteins. It also works on research that uses biomolecules as materials, such as lipid-coated enzymes and films made from DNA and lipids.
*Illustrative imageEnzymes in Organic Solvents and Supercritical Fluids
Coating an enzyme's surface with lipid molecules makes it soluble in organic solvents, allowing esterification and glycosylation reactions to proceed efficiently. In supercritical fluids, there is less solvation, and enzymes work better than in organic solvents.
*Illustrative imageFilms Made from DNA and Lipids
A complex made from anionic DNA and cationic lipids dissolves in organic solvents, and when cast and dried it forms a transparent, strong oriented DNA film. The lab investigates electrical conductivity along the DNA strands, liquid crystallinity, and use in photoelectric conversion devices.
*Illustrative imageMolecular Recognition Measured with a Quartz Crystal Microbalance
DNA, glycans, or proteins are immobilized on a quartz crystal microbalance, and the behavior of the molecules and enzymes that bind to them is tracked as changes in mass. It is also used to quantify translation, the process by which proteins are made from mRNA.
MembersFaculty
The members of the Mori Lab consist of faculty, master's and undergraduate students, administrative staff, and research assistants.
- Associate ProfessorToshiaki MoriPublications ↗
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Quartz resonators with front and back electrodes” Beaker / CC BY 3.0 (cropped)
- Enzymes in Organic Solvents and Supercritical Fluids: “Protein Crystal Malic Enzyme” NASA / Public domain (cropped)
- Films Made from DNA and Lipids: “DNA-molecule2” ynse from Poland / CC BY-SA 2.0 (cropped)
- Molecular Recognition Measured with a Quartz Crystal Microbalance: “Piezoelektryczny rezonator kwarcowy” Maciej Osmulski / CC BY-SA 3.0 (cropped)
- Related lab (金原研究室): “Lipid Bilayer” US gov / Public domain (cropped)
- Related lab (藤枝研究室): “Interference Colors from a Thin polymer Film” Tafaltens / CC BY-SA 3.0 (cropped)
- Related lab (小畠・三重研究室): “1RRX pdb group” Christopher King / CC BY 3.0 (cropped)
- Related lab (上野研究室): “Flu Self Assembly ( )” NIAID / CC BY 2.0 (cropped)
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