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Molecular Tumor Biology Lab
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The lab is an affiliated graduate school program based at a cancer center research institute, where it studies how cancer arises and develops new treatments.
AboutAbout the lab
Learning at the research institute of a dedicated cancer hospital
Molecular Tumor Biology is an affiliated graduate school program of the Graduate School of Medical and Pharmaceutical Sciences, Chiba University, based at the Chiba Cancer Center Research Institute.
The lab studies, at the molecular level, how cancer arises and what characterizes cancer cells and the cells surrounding them.
It aims to link these results to translational research and the development of new treatments.
Research takes place not on a Chiba University campus but at the Chiba Cancer Center Research Institute (Chuo Ward, Chiba City), which is attached to a specialized cancer hospital.
Key terms
- Organoid
- A small tissue that closely resembles an organ, made by growing cells in three dimensions. It can reproduce conditions close to those inside the body.
- Translational research
- Research that aims to bring the results of basic research to patients as new diagnostics and treatments.
- Inbred strain
- A strain of laboratory animals made genetically almost identical through repeated mating between siblings.
ResearchResearch themes
The lab clarifies, at the molecular level, how cancer arises and what characterizes cancer cells and the cells of the tumor microenvironment, with the aim of developing new treatments. Based in a research institute attached to a specialized cancer hospital, it carries out its research in cooperation with clinical departments.
*Illustrative imageRecreating Carcinogenesis with Organoids
The lab builds models that reproduce carcinogenesis in various organs by introducing genetic abnormalities commonly found in cancer into organoids made from normal mouse tissue. It has also succeeded in directly generating metastatic tumors from normal cells.
*Illustrative imagePatient-Derived Cancer Organoids
The lab collects organoids made from patients' cancers and examines the characteristics of the original tumors and how they respond to drugs. Focusing mainly on gynecologic cancers, it aims to overcome treatment resistance that arises from the diversity of cancer cells.
*Illustrative imageMouse Genes That Resist Carcinogenesis
Noting that inbred mice derived from wild populations in Japan are highly resistant to skin carcinogenesis, the lab searches for the genes responsible for this resistance using genetic approaches.
*Illustrative imageHow Endometrial Cancer Develops
The lab divides surgical specimens of endometrial cancer into fine regions and analyzes them. It investigates how a population of cells that gives rise to the cancer spreads within the uterus while accumulating mutations and becoming increasingly diverse.
MembersFaculty
The members of the Molecular Tumor Biology Lab consist of faculty at the Chiba Cancer Center Research Institute (Visiting Professors and Visiting Associate Professors) and graduate students.As of 2025
- Visiting ProfessorYoshitaka Hippo
- Visiting ProfessorYuichi Wakabayashi
- Visiting Associate ProfessorMasato Kawazu
- Visiting Associate ProfessorYasuhiko Kamikubo
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Chemical laboratory at the central cancer research labs” Unknown photographer / Public domain (cropped)
- Recreating Carcinogenesis with Organoids: “Cell Culture in a tiny Petri dish (cropped)” kaibara87 / CC BY 2.0 (cropped)
- Patient-Derived Cancer Organoids: “Fluorescence microscopy of the oral cancer cells” Korinna / CC BY 4.0 (cropped)
- Mouse Genes That Resist Carcinogenesis: “DNA Helix CPK” Ude / Public domain (cropped)
- How Endometrial Cancer Develops: “Illumina Hiseq 2000 sequencers, BGI Hong Kong sequencing room” Scotted400 / CC BY 3.0 (cropped)
- Related lab (医療行政学): “Mucosta (rebamipide) 100 mg tablets, Otsuka Pharmaceutical” 倶楽部オータム / CC BY-SA 3.0 (cropped)
- Related lab (重粒子線治療学): “PET-CT-Philips-2” Partynia / CC BY-SA 4.0 (cropped)
- Related lab (粘膜システム研究チーム): “Immunology laboratory at the central cancer research labs” Unknown photographer / Public domain (cropped)
- Related lab (免疫転写制御研究チーム): “Laboratory of Molecular Biology” Jynto (talk) / Public domain (cropped)
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