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Immune Transcriptional Regulation Lab
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A RIKEN research team investigating how immune cells differentiate, from the perspective of gene regulation.
AboutAbout the lab
Unraveling immune cell differentiation through how genes are read out.
The Immune Transcriptional Regulation Lab studies how the various immune cells that make up the immune system differentiate.
All cells in the body carry the same genome, and to become a specific type of cell, a program that reads out the necessary genetic information must be run.
Focusing on transcription factors, which are central to this process, the lab investigates the mechanisms of immune cell differentiation from the perspective of gene expression regulation.
The lab is a team at the RIKEN Center for Integrative Medical Sciences (Yokohama). As a cooperative graduate school program with Chiba University, it allows students to earn a degree while doing research here.
Key terms
- Genome
- The entire set of genetic information carried by the cells of an organism
- Transcription factor
- A protein that binds to DNA and regulates which genes are activated (expressed)
- Thymus
- An organ in the chest. It is where T cells, which function in immunity, mature
- Cooperative graduate school program
- A system in which a university and a research institute sign an agreement so that students can earn a university degree while doing research at the institute
NewsLab news
A joint research group has discovered a new mechanism that regulates gene expression specific to T cells
An international joint research group has discovered a way to manipulate the cells that give rise to regulatory T cells
An international joint research group has discovered a phosphorylation switch that determines T cell fate
A joint research group has developed a technology to degrade targeted proteins in living organisms
An international joint research group has clarified a new disease mechanism of inborn errors of immunity
ResearchResearch themes
The lab studies how the immune cells that make up the immune system differentiate, from the perspective of gene expression regulation. It aims to build a foundation for new ways of controlling immune cell differentiation, to clarify how diseases such as immunodeficiency, allergy, and autoimmune disease develop, and to develop new methods of control.
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MembersFaculty
The members of the Immune Transcriptional Regulation Lab consist of the team director, senior research scientists, research scientists, basic science special postdoctoral researchers, technical staff, special temporary staff, graduate student research associates, and international program associates.As of 2026
- Visiting ProfessorIchiro Taniuchi
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Laboratory of Molecular Biology” Jynto (talk) / Public domain (cropped)
- Immune cell differentiation and gene regulation: “Healthy Human T Cell” NIAID/NIH / Public domain (cropped)
- Related lab (ヒト疾患モデル研究チーム): “Sterile 24-Well Cell Culture Plate Used in Laboratory Research” Gannu03 / CC BY-SA 4.0 (cropped)
- Related lab (粘膜システム研究チーム): “Immunology laboratory at the central cancer research labs” Unknown photographer / Public domain (cropped)
- Related lab (免疫細胞治療研究チーム): “Bioreactor for cell culture in the laboratory” Habin Zhang / CC BY-SA 4.0 (cropped)
- Related lab (医療行政学): “Mucosta (rebamipide) 100 mg tablets, Otsuka Pharmaceutical” 倶楽部オータム / CC BY-SA 3.0 (cropped)
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