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Mucosal System Lab
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A RIKEN research team exploring intestinal immunity and the roles of gut bacteria.
AboutAbout the lab
Studying gut immunity and the bacteria that live in the gut.
The Mucosal System Lab studies the mechanisms of immunity in the intestine.
The lab investigates how M cells, specialized cells that take bacteria and viruses from inside the gut into immune tissue, function and how they form.
The lab also studies how the gut microbiota interacts with its host and how this affects bodily functions and disease.
The lab is a team at the RIKEN Center for Integrative Medical Sciences (Yokohama). As a cooperative graduate school program with Chiba University, it allows students to earn a degree while doing research here.
Key terms
- M cells
- A type of cell on the surface of the intestine. It takes up bacteria, viruses, and other material from inside the gut and passes them to immune tissue
- Gut microbiota
- The community of many different types of bacteria that live in the intestine
- Host
- The organism in which bacteria and other microbes live. Here, it means humans and animals
- Cooperative graduate school program
- A system in which a university and a research institute sign an agreement so that students can earn a university degree while doing research at the institute
NewsLab news
A joint research group has uncovered part of the mechanism by which thermophilic bacteria improve diarrhea in calves
An international joint research group has clarified the immune mechanism that operates in visceral fat during peritonitis
A joint research group has confirmed a relationship between fermented feed, heat tolerance in chickens, and the gut environment
A joint research group has clarified the mechanism by which smoking relieves symptoms of ulcerative colitis
An international joint research group has found that the gut microbiota is also disrupted in patients with periodontal disease
ResearchResearch themes
The lab studies the mechanisms of intestinal immunity and the effects of the gut microbiota on the host's body. It focuses in particular on clarifying how M cells, which take bacteria and viruses in from the gut lumen, function and how they form.
*Illustrative imageFunctions and formation of M cells
The lab studies the functions and differentiation mechanisms of M cells, which are specialized in taking large particles such as bacteria and viruses from inside the gut into the intestinal lymphoid tissue.
*Illustrative imageInteractions between gut bacteria and the host
The lab studies how the gut microbiota living in the intestine, through its interactions with the host, affects the host's bodily functions and disease.
MembersFaculty
The members of the Mucosal System Lab consist of the team director, research scientists, special postdoctoral researchers, research associates, expert technicians, technical staff, and visiting scientists.As of 2026
- Visiting ProfessorHiroshi Ono
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Immunology laboratory at the central cancer research labs” Unknown photographer / Public domain (cropped)
- Functions and formation of M cells: “Colorized transmission electron micrograph of monkeypox virus particles (green)” National Institute of Allergy and Infectious Diseases (NIAID) / CC BY 2.0 (cropped)
- Interactions between gut bacteria and the host: “Human microbiome NHGRI” en:National Human Genome Research Institute / Public domain (cropped)
- Related lab (免疫転写制御研究チーム): “Laboratory of Molecular Biology” Jynto (talk) / Public domain (cropped)
- Related lab (免疫細胞治療研究チーム): “Bioreactor for cell culture in the laboratory” Habin Zhang / CC BY-SA 4.0 (cropped)
- Related lab (ヒト疾患モデル研究チーム): “Sterile 24-Well Cell Culture Plate Used in Laboratory Research” Gannu03 / CC BY-SA 4.0 (cropped)
- Related lab (医療行政学): “Mucosta (rebamipide) 100 mg tablets, Otsuka Pharmaceutical” 倶楽部オータム / CC BY-SA 3.0 (cropped)
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