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Pharmacology Lab
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A pharmacology lab that aims to develop new drugs by studying how substances enter and leave cells.

AboutAbout the lab
Understanding drug action through how substances enter and exit cells
The lab studies the function of transporters, which carry substances in and out of cells.
It investigates transporters of uric acid, drugs, and amino acids, aiming to develop new uric acid-lowering drugs and anticancer drugs.
Its other pillar is research on neuropeptides, examining how the brain regulates eating and drinking behavior.
Founded in 1924 as the Department of Pharmacology at Chiba Medical College, the lab marked its 100th anniversary in 2024.
Key terms
- Transporter
- A protein in the cell membrane that carries substances such as sugars and amino acids into and out of the cell
- Uric acid
- A substance produced when purines are broken down in the body. When it accumulates in the blood, it can cause gout and urinary tract stones
- Neuropeptide
- A small protein released from brain and nerve cells that regulates functions such as appetite and drinking
NewsLab news
A paper by a master's student has been accepted
A master's student won the Top Award at the Kuroshio Conference
A master's student won the Hikawa Prize at the Hikawa Forum
A student won the Outstanding Student Award in the Innovative Medicine CHIBA Program for Leading Graduate Schools
A master's student won the Graduate Student Presentation Award at APPW2025
ResearchResearch themes
The lab has two pillars: research on transporters, which carry substances in and out of cells, and research on neuropeptides. By clarifying how transport works, it aims to lead to the development of new drugs, and it also seeks to uncover how the brain regulates behavior.
*Illustrative imageUric Acid Transporters
When too much uric acid is reabsorbed in the renal tubules of the kidney, hyperuricemia results. The lab aims to develop new uric acid-lowering drugs that lower blood uric acid levels by regulating transporter function.
*Illustrative imageOrganic Acid and Drug Transporters
Inside the body, drugs take the form of organic acids and are absorbed, distributed, metabolized, and excreted by transporters. The lab studies how transport activity is regulated and how genetic polymorphisms change transporter function.
*Illustrative imageAmino Acid Transporters
Amino acid uptake is thought to be increased in tumor cells and immune cells. The lab aims to develop anticancer drugs and immunosuppressants that suppress cell proliferation by blocking these transporters.
*Illustrative imageMonocarboxylate Transporters
MCTs, which carry lactate and ketone bodies, are also found in glial cells in the brain. Using a mouse middle cerebral artery occlusion model, the lab analyzes the role that MCTs in astrocytes play when blood flow to the brain is interrupted.
MembersFaculty
The lab's members consist of faculty, technical staff, graduate students, and collaborating researchers.As of 2026
- ProfessorNaohiko Anzai
- Associate ProfessorHirofumi Hashimoto
- Assistant ProfessorYuri Hirayama
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Structure of GLUT1” ChemPro / CC0 (cropped)
- Uric Acid Transporters: “Fluorescent uric acid” Bobjgalindo / CC BY-SA 4.0 (cropped)
- Organic Acid and Drug Transporters: “Multiwell cell culture plates-set” Lilly_M / CC BY-SA 3.0 (cropped)
- Amino Acid Transporters: “Amino Acid Structure” Techguy78 / CC BY-SA 4.0 (cropped)
- Monocarboxylate Transporters: “L-Lactic acid molecule ball” Jynto (talk) / CC0 (cropped)
- Related lab (和漢診療学): “Chinese Medicine” Dr. Bret Mosher / CC BY-SA 4.0 (cropped)
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