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Clinical Pharmacy Lab
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A lab that studies how drugs work and cause side effects, based on genetic polymorphisms and drug combinations.
AboutAbout the lab
Finding appropriate drug use by studying how drugs behave in the body.
The Clinical Pharmacy Lab analyzes genetic polymorphisms in drug-metabolizing enzymes and transporter proteins, and studies drug-drug interactions.
Focusing on immunosuppressants for kidney transplant patients, antiarrhythmic drugs, and tyrosine kinase inhibitors, the lab examines how genetic differences and drug combinations affect treatment.
The lab also analyzes side effects and interactions of Kampo (traditional Japanese herbal) medicines and works on predicting blood drug concentrations.
Key terms
- Genetic polymorphism
- Differences in the base sequence of the same gene from person to person. It is examined in genes such as those for drug-metabolizing enzymes
- Drug-drug interaction
- When multiple drugs are used at the same time, one drug affects the action or side effects of another
- Drug-metabolizing enzyme
- An enzyme responsible for the reactions that convert drugs entering the body into other substances
NewsLab news
View More ↗ResearchResearch themes
The Clinical Pharmacy Lab centers its research on analyzing genetic polymorphisms in drug-metabolizing enzymes, transporter proteins, and similar targets, and on drug-drug interactions. It also analyzes side effects and interactions of Kampo medicines and works on predicting blood drug concentrations.
*Illustrative imageIndividualizing Immunosuppressant Therapy for Kidney Transplant Patients
This research analyzes polymorphisms in drug-metabolizing enzyme genes for patients who have received a kidney transplant, in order to determine the dosing method best suited to each patient's immunosuppressant therapy.
*Illustrative imageAntiarrhythmic Drug Effects and Genes
The lab investigates how the effects of antiarrhythmic drugs vary depending on polymorphisms in the CYP2D6 gene and on mutations in genes related to cardiac sodium channels.
*Illustrative imageInteractions and Side Effects of Tyrosine Kinase Inhibitors
The lab studies drug-drug interactions and side effects that arise when tyrosine kinase inhibitors are used. This is one of the items under the lab's research on genetic polymorphism analysis and drug-drug interactions.
*Illustrative imageAnalysis of Side Effects and Interactions of Kampo Medicines
Based on pharmacokinetics, the lab analyzes side effects and interactions of Kampo medicines. It is listed as "Other" research in the lab's research overview.
MembersFaculty
The lab's members consist of faculty, hospital lecturers, collaborators, and doctoral students.
- ProfessorMasato Homma
- Associate ProfessorKosuke Doki
- Hospital LecturerYoshiharu Suzuki
- Hospital LecturerNaoaki Hashimoto
- Hospital LecturerShota Ichimizu
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Pills and medicines 02” BuhaM / CC BY-SA 4.0 (cropped)
- Individualizing Immunosuppressant Therapy for Kidney Transplant Patients: “APHIS-Moore Air Base in Texas-Plant Protection and Quarantine Science and Technology Insect Management and Molecular Diagnostics Laboratory (20230621-CDP-APHIS-0498)” USDAgov / Public domain (cropped)
- Antiarrhythmic Drug Effects and Genes: “Normal electrocardiogram” medipics1066 / CC BY 2.0 (cropped)
- Interactions and Side Effects of Tyrosine Kinase Inhibitors: “Hospital Pharmacy” User:Mattes / Public domain (cropped)
- Analysis of Side Effects and Interactions of Kampo Medicines: “Maou” Hanabishi / CC BY-SA 3.0 (cropped)
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- Related lab (Ophthalmology Lab): “Consultation des yeux A l'hôpital Laquintinie de Douala 15” Destiny Deffo / CC BY-SA 4.0 (cropped)
- Related lab (Respiratory Medicine Lab): “Chest x-ray plain film normal” Ptrump16 / CC BY-SA 4.0 (cropped)
- Related lab (Emergency and Critical Care Medicine Lab): “Bruce Woodbury Beltway Medical Incident 5” Noah Wulf / CC BY-SA 4.0 (cropped)
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