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Neurology Lab
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A lab working to elucidate the mechanisms of neurodegenerative diseases and develop new therapeutic drugs.
AboutAbout the lab
Know the present, predict the future, change the future.
The Neurology Lab belongs to the neurology field in the Faculty of Medicine at the University of Tsukuba, and studies the mechanisms of neurodegenerative diseases and the development of new therapeutic drugs.
Its clinical department is called Neurology (noshinkei-naika in Japanese, literally "brain and nerve internal medicine"), and at the University Hospital it provides specialized care for REM sleep behavior disorder, Parkinson's disease, amyotrophic lateral sclerosis, and myasthenia gravis.
Its research covers both basic research that examines cellular mechanisms and clinical research that examines diagnostic and therapeutic methods.
In the lab practicum for students in the College of Medicine, students collect and analyze data themselves, aiming to understand disease mechanisms and treatment.
Key terms
- Autophagy
- A mechanism by which cells break down and recycle unneeded materials inside themselves
- Ferroptosis
- A type of iron-dependent cell death caused by excessive oxidation of phospholipids
- RNA editing
- Modification of genetic information that occurs when RNA is made from DNA or afterward
NewsLab news
A PhD student's research protocol paper published in Neurology and Therapy
A PhD student's research paper published in Environment International
A PhD student received the FY2026 Academic Encouragement Award for Hospital Physicians from the Ibaraki Medical Association
Research paper by Assistant Professor Tetsushi Kataura published in FEBS Letters
ResearchResearch themes
The lab conducts basic research aimed at elucidating the mechanisms of intractable, age-related neurodegenerative diseases and developing new therapeutic drugs. It also carries out clinical research on patients with REM sleep behavior disorder, Alzheimer's disease, and myasthenia gravis.
*Illustrative imageBiomarker research on neurodegenerative diseases
The lab is searching for markers that allow Parkinson's disease and Alzheimer's disease to be diagnosed more simply and quickly. In addition to blood, it is pursuing biomarker research using sebum collected from the face as a sample.
*Illustrative imageDeveloping autophagy-enhancing drugs
Some of the abnormal protein aggregates seen across neurodegenerative diseases are degraded by autophagy. Focusing on the link with lysosomal function, the lab is searching for autophagy-enhancing drugs with new mechanisms in cell and animal models of Parkinson's disease.
*Illustrative imageRNA editing abnormalities and biomarkers for ALS
The lab studies the pathology of amyotrophic lateral sclerosis (ALS) from the perspective of abnormal RNA editing. It found that the RNA editing rate in cerebrospinal fluid is lower in sporadic ALS, and is now examining whether RNA in blood can serve as an indicator.
*Illustrative imageFerroptosis and the pathology of neurodegenerative diseases
The lab studies how ferroptosis contributes to neurodegeneration in Parkinson's disease and in the group of diseases in which iron accumulates in the brain. It plans to test this using patients' serum and MRI images, iPS cell-derived neurons, and cultured cell models.
MembersFaculty
Members of the Neurology Lab are faculty members, residents, graduate students (PhD and master's), and students from the College of Medicine, the College of Medical Sciences, and the College of Biological Sciences.As of 2026
- ProfessorShinji Saiki
- Project Associate ProfessorKiyotaka Nakamagoe
- Hospital Associate ProfessorYasushi Tomidokoro
- LecturerAyako Shioya
- LecturerMakoto Terada
- LecturerMikito Hayakawa
- LecturerTakashi Hosaka
- LecturerMotoki Fujimaki
- Hospital LecturerNaomi Mamada
- Assistant ProfessorTetsushi Kataura
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Automated confocal image reader” Neil Emans IPK / CC BY-SA 3.0 (cropped)
- Biomarker research on neurodegenerative diseases: “Checking Blood Sample ( )” National Eye Institute / CC BY 2.0 (cropped)
- Developing autophagy-enhancing drugs: “Autophagy” Cheung and Ip / CC BY 3.0 (cropped)
- RNA editing abnormalities and biomarkers for ALS: “Blood collection renal function test tube” Fumikas Sagisavas / CC0 (cropped)
- Ferroptosis and the pathology of neurodegenerative diseases: “NCCT Brain Imaging” Goleisureintl / CC BY 4.0 (cropped)
- Related lab (Chemical Biology and IT Drug Discovery Lab): “CSIRO ScienceImage 2589 Shape of Protein Backbone” division, CSIRO / CC BY 3.0 (cropped)
- Related lab (Hematology Lab): “Eosinophil blood smear” Bobjgalindo / CC BY-SA 4.0 (cropped)
- Related lab (Digital Health Lab): “Ordinateur portable de Wikimedia France faisant tourner le logiciel Linto et un dashboard développé pour l'occasion pour la transcription en temps réel (49071)” Don-vip / CC BY-SA 4.0 (cropped)
- Related lab (Psychiatry Lab): “FEMA - 30406 - Baptist disaster relief workers cooking in Kansas” Greg Henshall / Public domain (cropped)
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