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Molecular Genetic Epidemiology Lab
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A lab that aims to elucidate the etiology of connective tissue diseases through human genome diversity.
AboutAbout the lab
Uncovering the causes of connective tissue diseases through human genome diversity.
The Molecular Genetic Epidemiology Lab, under the keywords "human genome diversity and disease," aims to elucidate the etiology of connective tissue diseases, which are systemic autoimmune diseases.
Some of the inherited differences in DNA sequence between individuals (variants) are thought to be involved in disease susceptibility.
Focusing on ANCA-associated vasculitis, systemic lupus erythematosus, and systemic sclerosis, the lab is searching for causes, molecular targets, and biomarkers.
Responses to drugs and the occurrence of side effects differ from patient to patient, and the lab also aims to contribute to precision medicine.
Key terms
- Connective tissue diseases
- Representative systemic autoimmune diseases. Besides the immune system, organs, joints, blood vessels, and connective tissues are affected.
- Disease susceptibility
- A constitution that makes a person prone to a certain disease. Individual differences in genomic DNA are involved.
- Variant
- An individual difference in the DNA sequence a person is born with. Variants present at a certain frequency in the general population are called polymorphisms.
- precision medicine
- Medicine tailored to each individual's constitution, which is more effective and safer.
NewsLab news
A paper investigating the genetic association of eosinophilic granulomatosis with polyangiitis was published in RMD Open
The lab joined the Genetic Medicine Group of the Institute of Medicine
ResearchResearch themes
Connective tissue diseases and rheumatoid arthritis, which are representative systemic autoimmune diseases, still have unclear etiologies and no fundamental treatments. Focusing on ANCA-associated vasculitis, systemic lupus erythematosus, and systemic sclerosis, the lab uses human genome analysis to elucidate their underlying etiology and to search for molecular targets and biomarkers.
View More ↗MembersFaculty
The Molecular Genetic Epidemiology Lab consists of faculty members, graduate students, undergraduate students, and visiting researchers.As of 2026
- Assistant ProfessorAya Kawasaki
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Whitney Genetics Lab PCR Machine ( )” U.S. Fish and Wildlife Service - Midwest Region / Public domain (cropped)
- Related lab (Connective Tissue Disease, Rheumatology, and Allergy Lab): “U.S. Air Force Staff Sgt. Thomas C. Sullivan Jr., a laboratory technician assigned to the 319th Medical Support Squadron, places a medical sample into a test tube rack at the medical laboratory on Grand Forks 130522-F-JB669-061” Staff Sgt. Luis Loza Gutierrez / Public domain (cropped)
- Related lab (Dermatology Lab): “Dermatoscopy Nevus Reticular” Philipp Tschandl / CC BY-SA 4.0 (cropped)
- Related lab (Bioinformatics Lab): “Eppendorf epMotion 5075 liquid handling robot” Magnus Manske / CC BY-SA 3.0 (cropped)
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