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Pathophysiological and Molecular Pharmaceutics Lab
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The lab analyzes drugs and diseases at the molecular level from inside a hospital.
AboutAbout the lab
Analyzing disease and drugs from inside a hospital
The Pathophysiological and Molecular Pharmaceutics Lab is led by the Professor who is also Director of the Department of Pharmacy at Tohoku University Hospital, and it is a cooperating chair of the Faculty of Pharmaceutical Sciences and the Graduate School of Pharmaceutical Sciences.
Taking advantage of being located inside a hospital, the lab conducts research aimed at providing patients with safe, high-quality drug therapy and at elucidating the mechanisms of disease pathophysiology.
As its core technologies, the lab uses liquid chromatography and mass spectrometry to analyze molecules and drugs in the body with high sensitivity.
In the School of Medicine and the Graduate School of Medicine, the lab serves as a cooperating chair in Clinical Pharmacy, and it carries out its research in collaboration with the clinical departments of the university hospital and with other labs.
Key terms
- Biomarker
- A substance in the body that serves as an indicator of the presence or state of a disease
- Liquid chromatography–tandem mass spectrometry
- An analytical method that separates the components of a mixture and measures the mass of each to determine its type and amount
- GWAS
- An analysis that examines the genomes of many people to find genetic differences associated with diseases or adverse drug reactions
NewsLab news
A doctoral student received the Student Excellent Presenter Award at the 68th Annual Meeting of the Japanese Conference on the Biochemistry of Lipids
A student received the Student Excellent Presentation Award at the 146th Annual Meeting of the Pharmaceutical Society of Japan
A first-author paper by a doctoral student was published in Journal of Pharmaceutical and Biomedical Analysis Open
An undergraduate student received a Student Award at the 65th Annual Meeting of the Japan Society of Clinical Chemistry
ResearchResearch themes
The lab elucidates the pathophysiology and causes of disease at the molecular level, with the aim of creating personalized medicine. The research page lists the work of each faculty member, ranging from elucidating pathophysiology through chemical analysis to pharmacoepidemiology that examines drug safety for pregnant women and their children.
*Illustrative imageDisease biomarkers and adverse events
The lab studies how to find and accurately measure biological substances characteristic of a disease (biomarkers) and use them for diagnosis, as well as the mechanisms by which adverse drug events occur. It searches for such biomarkers in conditions including Niemann-Pick disease type C and renal cell carcinoma, using liquid chromatography–tandem mass spectrometry.
*Illustrative imageResearch toward practicing personalized medicine
Aiming at personalized drug therapy that uses the optimal drug at the optimal dose for each patient, the lab works on searching for biomarkers that predict the activity of drug-metabolizing enzymes, developing systems for measuring blood drug concentrations, and searching for markers for the early detection of drug-induced liver injury.
*Illustrative imageDrug safety for pregnant women and children
Information on the safety of medication use by pregnant women and their children is lacking worldwide. Using multiple birth cohort studies and databases of insurance claims and electronic medical records, the lab investigates matters such as the association between medication use during pregnancy and congenital malformations, growth, and development in children.
*Illustrative imageAnalyzing disease risk with family information taken into account
The lab conducts research that uses GWAS taking family information into account to extract, with high precision, the genomic factors involved in the onset of various diseases and adverse drug reactions. One project takes parental genotypes into account to examine SNPs associated with NAFLD and liver fibrosis.
MembersFaculty
The members of the Pathophysiological and Molecular Pharmaceutics Lab consist of faculty, faculty with concurrent appointments, lab researchers, and doctoral and undergraduate students.As of 2026
- ProfessorNariyasu Mano
- Associate ProfessorMasamitsu Maekawa
- Assistant ProfessorRyosuke Segawa
- Assistant ProfessorMasaki Kumonoshiro
- Associate ProfessorMayumi Sato
- ProfessorTaku Obara
- Assistant ProfessorAoi Noda
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Ion chromatograph in combination with a mass spectrometer, in CAFIA laboratory, Czech Republic” Sarka Na kopci / CC BY-SA 4.0 (cropped)
- Disease biomarkers and adverse events: “Shimadzu Mixed” Elemimele / CC BY-SA 4.0 (cropped)
- Research toward practicing personalized medicine: “Common Diabetes oral medication” Joekyabby1 / CC BY-SA 4.0 (cropped)
- Drug safety for pregnant women and children: “Newborn infant, Newborn baby girl, Moscow, Russia” Vyacheslav Argenberg / CC BY 4.0 (cropped)
- Analyzing disease risk with family information taken into account: “DNA Double Helix by NHGRI” National Human Genome Research Institute / Public domain (cropped)
- Related lab (ゲノム医療薬学分野): “Mini Pipette for laboratory and medical uses” Emicropipette / CC BY-SA 4.0 (cropped)
- Related lab (医療薬学教育研究センター): “Pharmacist in the pharmacy” Akeeb Feroz / CC BY-SA 4.0 (cropped)
- Related lab (界面物性化学分野): “Advanced Measurement Laboratory; Sample Prep, Chemical Micro and Nanoanalysis ( )” National Institute of Standards and Technology / Public domain (cropped)
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