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Genomic Medicine Pharmacy Lab
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A pharmacy lab that explores individual differences in drug response through the genome.
AboutAbout the lab
Reading individual differences in drug response from the genome.
The Genomic Medicine Pharmacy Lab studies why the same drug can work differently, or cause side effects more easily, from person to person, by looking at differences in the genome (genetic information).
Focusing on genetic polymorphisms in enzymes involved in drug metabolism, the lab aims to lead to choosing drugs and determining doses suited to each individual patient.
The lab was newly launched in April 2025, and its website also introduces it under the name "Hiratsuka PGx Lab."
Key terms
- Genetic polymorphism
- DNA sequences in the human genome that differ slightly from person to person. One factor behind individual differences in drug response and side effects
- Drug-metabolizing enzyme
- Enzymes that break down or chemically modify drugs that enter the body. Their activity varies between individuals and affects how well a drug works
- Personalized pharmacotherapy
- An approach to treatment that chooses the type, dose, and timing of drugs according to each patient's constitution
NewsLab news
A master's student won the Best Presentation Award (poster category) at the Annual Meeting of the Japanese Society of Clinical Pharmacology and Therapeutics
A paper by Associate Professor Miyauchi and colleagues was published in Biochemical and biophysical research communications
A student's research results were announced in a press release
A paper by Professor Hiratsuka and colleagues was published in Biochemical Pharmacology
A paper by Associate Professor Miyauchi and colleagues was published in The Journal of biological chemistry
ResearchResearch themes
The lab studies how differences in each patient's genome sequence affect how well drugs work and how likely side effects are. By clarifying those differences at the molecular level, it aims to realize personalized pharmacotherapy.
*Illustrative imageResponse to Anticancer Drugs and Genetic Polymorphisms
Using DNA from cancer patients, the lab searches for genetic polymorphisms involved in response to taxane, platinum, and fluoropyrimidine anticancer drugs. It also aims to develop test kits that detect the polymorphisms found.
*Illustrative imageComprehensive Analysis of Variants in Drug-Metabolizing Enzymes
Based on whole-genome sequence data from the Tohoku Medical Megabank Organization, the lab artificially creates variant forms of 16 major drug-metabolizing enzymes and examines changes in their activity. It aims to build a panel that predicts drug pharmacokinetics from genotype.
*Illustrative imagePreventing Drug-Induced Hearing Loss
People with polymorphisms such as 1555A>G in mitochondrial DNA are reported to be prone to hearing loss from aminoglycoside antibiotics. The lab works on building a simple genetic test and a system for finding compounds that cause hearing loss.
MembersFaculty
The members of the Genomic Medicine Pharmacy Lab are faculty members, research fellows, and doctoral, master's, and undergraduate students. Faculty members of the Medical Pharmacy Education and Research Center also take part in supervision.As of 2026
- ProfessorMasahiro Hiratsuka
- Associate ProfessorYu Miyauchi
- Associate ProfessorTakamitsu Sasaki
- Assistant ProfessorHayato Yokota
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Mini Pipette for laboratory and medical uses” Emicropipette / CC BY-SA 4.0 (cropped)
- Response to Anticancer Drugs and Genetic Polymorphisms: “Chemotherapy vials” Bill Branson (Photographer) / Public domain (cropped)
- Comprehensive Analysis of Variants in Drug-Metabolizing Enzymes: “Pipette gallery” User:Squidonius, myself, and User:Beliason (assumed). / CC BY-SA 4.0 (cropped)
- Preventing Drug-Induced Hearing Loss: “Hearing aid variety” Vilma Liella / CC BY-SA 2.0 (cropped)
- Related lab (Medical Pharmacy Education and Research Center Lab): “Pharmacist in the pharmacy” Akeeb Feroz / CC BY-SA 4.0 (cropped)
- Related lab (Pathophysiological and Molecular Pharmaceutics Lab): “Ion chromatograph in combination with a mass spectrometer, in CAFIA laboratory, Czech Republic” Sarka Na kopci / CC BY-SA 4.0 (cropped)
- Related lab (Cancer Chemotherapy Pharmacy Lab): “Pharmacy Team Recognized on National Pharmacist Day (8197386)” U.S. Navy NMRTC by Emily McCamy / Public domain (cropped)
- Related lab (Drug Delivery Lab): “Redox-Responsive Drug Delivery” BioRender.com / CC0 (cropped)
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