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Oral and Maxillofacial Tissue Development Lab
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The lab investigates the mechanisms of the development, repair, and calcification of teeth and bone.

AboutAbout the lab
Exploring how teeth and bone form and harden
The Oral and Maxillofacial Tissue Development Lab studies the development and repair of bone and teeth, targeting tissues closely related to dentistry such as teeth, bone, cartilage, and gingiva.
The lab investigates when, where, and how molecules of the extracellular matrix surrounding cells function while bones and teeth are formed.
The lab also explores calcification, the hardening of teeth and bone, from the perspective of the roles of cells and the extracellular matrix.
In the School of Dentistry's education, the lab is in charge of courses on the tissue structure of the human body, the oral cavity, and teeth.
Key terms
- Extracellular matrix
- Material surrounding cells. It serves as a foundation for cell differentiation and determines the properties of tissues.
- Calcification
- The phenomenon by which teeth and bone harden. It occurs when calcium phosphate crystals are deposited in the extracellular matrix.
- Development
- The process by which tissues such as teeth and bone are formed.
ResearchResearch themes
The lab conducts research on tissues closely related to dentistry, including teeth, bone, cartilage, and gingiva. Its themes are the development and repair of bone and teeth, the function of the extracellular matrix, and calcification.
*Illustrative imageDevelopment and Repair of Bone and Teeth
During the repair of bone and tooth tissue, basic biological phenomena seen in development are reproduced in a modified form. The lab aims to clarify what the two processes have in common and what is specific to each.
*Illustrative imageFunctions of the Extracellular Matrix
Bone and teeth are rich in extracellular matrix. The lab investigates when, where, and how various extracellular matrix molecules function as these tissues are formed.
*Illustrative imageCalcification: How Teeth and Bone Harden
The lab studies calcification, the phenomenon by which teeth and bone "harden." Calcification occurs when calcium phosphate crystals are deposited in the extracellular matrix, and the lab explores the roles played by cells and the extracellular matrix in this process.
MembersFaculty
- ProfessorAkihiro Hosoya
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Slide under a microscope” Waughd / CC BY-SA 4.0 (cropped)
- Development and Repair of Bone and Teeth: “Bones of skeletal system” https://www.scientificanimations.com/ / CC BY-SA 4.0 (cropped)
- Functions of the Extracellular Matrix: “Connective Tissue Loose Aerolar ( )” Berkshire Community College Bioscience Image Library / CC0 (cropped)
- Calcification: How Teeth and Bone Harden: “Tricalcium-phosphate-3D-balls-ionic” Hoa112008 / Public domain (cropped)
- Related lab (口腔病理学分野): “Hooke Microscope-03000276-FIG-4” 作者不詳 / Public domain (cropped)
- Related lab (小児発達歯科学分野): “Dentist in Mexico attending a child” Miguel Angel Omaña Rojas / CC BY 4.0 (cropped)
- Related lab (口腔生理学分野): “Adherent cells of Capsaspora owczarzaki (filasterea)” Multicellgenome Lab / CC BY 2.0 (cropped)
- Related lab (予防歯科学分野): “Dental hygiene students help kids with free clinic ( )” Germanna CC / CC BY 2.0 (cropped)
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