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Dental and Oral Anesthesiology Lab
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A lab that aims to develop new treatments starting from clinical questions in dental anesthesia.
AboutAbout the lab
Aiming to develop new treatments from questions that arise in clinical practice
The Dental and Oral Anesthesiology Lab starts from questions that arise in clinical practice and conducts research aimed at developing new treatments.
The lab studies treatments for bronchospasm, asthma, and COPD, the mechanisms by which orofacial pain arises, an AI-based automated anesthesia system, and ways to increase regulatory T cells.
The lab accepts requests for tours of the hospital and lab, and consultations about entering graduate school, at any time.
Key terms
- Bronchospasm
- A condition in which the bronchi, the airways, constrict and make it difficult for air to pass through
- Regulatory T cells
- A type of T cell that suppresses excessive immune responses. Abbreviated as Treg.
- closed-loop
- A method that keeps automatically adjusting the control based on measured results. Here it refers to automated control of anesthesia.
NewsLab news
A student of the Faculty of Dentistry received the Best Presentation Award at the 73rd Annual Meeting of the Japanese Society of Anesthesiologists
A paper by Lecturer Yukinori Tanaka and colleagues on a new treatment technique for apical periodontitis exacerbated by enteritis has been published
A paper by Lecturer Yukinori Tanaka and colleagues on the role of gut microbiota in sublingual immunotherapy has been published
A clinical staff member received the Kim's Global Presenter Award
A paper by Associate Professor Hiroshi Hoshijima and colleagues on an AI-based analysis of risk factors for postoperative nausea and vomiting has been published
ResearchResearch themes
Starting from questions that arise in clinical practice, the lab aims to lead to the development of new treatments. It works on airway diseases, orofacial pain, automated anesthesia systems, immune balance, and more.
*Illustrative imageNew treatments for bronchospasm, asthma, and COPD
Aiming to develop entirely new treatments, the lab searches for whether new receptors are expressed and investigates how their signals are transmitted. It has worked closely for many years with the basic research division of the Department of Anesthesiology at Columbia University's medical school.
*Illustrative imageElucidating the mechanisms by which orofacial pain arises
The lab uses multiscale brain function imaging that combines quantitative activity-induced manganese-enhanced MRI with in vivo Ca2+ imaging. With this technology, it works to elucidate the mechanisms by which orofacial pain arises.
*Illustrative imageDevelopment of a robotic anesthesia system
In collaboration with the Graduate School of Engineering, the lab is developing an AI-based closed-loop automated anesthesia system.
*Illustrative imageDeveloping treatments that increase regulatory T cells
An imbalance between regulatory T cells and effector T cells is thought to lead to autoimmune and allergic diseases. The lab works on treatments that increase regulatory T cells to restore the balance, and on elucidating the mechanisms involved.
MembersFaculty
The members of the Dental and Oral Anesthesiology Lab consist of faculty members, clinical assistant professors, clinical staff, graduate students, and external clinical professors and part-time lecturers.As of 2026
- ProfessorKentaro Mizuta
- Associate ProfessorHiroshi Hoshijima
- LecturerYukinori Tanaka
- Assistant ProfessorMakoto Yasuda
- Assistant ProfessorHaruka Sasaki
- Clinical Assistant ProfessorMidori Maekawa
- Clinical Assistant ProfessorShiori Sasaki
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Veterinary anesthesia machine close-up in Newark, New Jersey” Veterinarian Pet Alliance / CC BY 4.0 (cropped)
- New treatments for bronchospasm, asthma, and COPD: “Asthma Inhaler ( )” NIAID / CC BY 2.0 (cropped)
- Elucidating the mechanisms by which orofacial pain arises: “CSIRO ScienceImage 3488 Patient undergoing MRI scan in Westmead Hospital Sydney” Westmead Hospital, CSIRO / CC BY 3.0 (cropped)
- Development of a robotic anesthesia system: “Robotic CyberKnife at St. Marys Of Michigan” Communications Manager / CC BY 2.0 (cropped)
- Developing treatments that increase regulatory T cells: “Healthy Human T Cell” NIAID/NIH / Public domain (cropped)
- Related lab (Dental Pharmacology Lab): “Patch clamp schematic 1” PeaBrainC / CC BY-SA 4.0 (cropped)
- Related lab (Regenerative Dental Engineering Lab): “Dental-implant-illustration” Alexmit art / CC BY-SA 4.0 (cropped)
- Related lab (Endodontology and Periodontology Lab): “A dental chair in a dentist clinic in North Carolina, United States” Harrison Keely / CC BY 4.0 (cropped)
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