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Dental Pharmacology Lab
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A lab that explores the workings of living organisms at the molecular level, from ion channels to sensors in the mouth.
AboutAbout the lab
Clarifying the operating principles of living organisms at the molecular level.
The lab combines electrophysiological and molecular biological methods to clarify the operating principles of living organisms at the molecular level.
It also searches for biomolecules that serve as drug targets.
Its subjects of study include ion channels in the cell membrane, neurotransmitter receptors, and the release of neurotransmitters.
The lab also studies the mechanisms of the sensors responsible for sensation in the mouth.
Key terms
- Ion channel
- A protein in the cell membrane that forms a pore through which ions pass. It is also involved in regulating intracellular Ca2+ concentration
- TRP channel
- A type of ion channel that monitors the environment outside the cell. It has attracted attention in recent years
- Neurotransmitter
- A chemical substance that a neuron releases to pass information on to the next cell
ResearchResearch themes
The lab clarifies how living organisms function at the molecular level and searches for biomolecules that serve as drug targets. Combining electrophysiological and molecular biological methods, it investigates the regulation of intracellular Ca2+ concentration, the release of neurotransmitters, and related topics.
*Illustrative imageCa2+ regulation and neurotransmitter release
The lab studies ion channels in the plasma membrane that are involved in regulating intracellular Ca2+ concentration, as well as neurotransmitter receptors. It also studies the release of neurotransmitters, a process in which Ca2+ plays a major role.
*Illustrative imageCa2+ channels and TRP channels
The lab studies P-type (Cav2.1) voltage-gated Ca2+ channels, which are involved in central nervous system diseases such as ataxia, familial migraine, and spinocerebellar degeneration. It is also advancing research on TRP channels, which monitor the extracellular environment.
*Illustrative imageMechanisms of sensors in the mouth
The mouth has delicate and diverse sensors for pain, thermal sensation, touch and pressure, and more, but many aspects of how they operate at the molecular and cellular levels remain unclear. The lab believes this research can contribute to understanding sensors throughout the body and to safer dental treatment.
MembersFaculty
- ProfessorMinoru Wakamori
- Associate ProfessorTakashi Nakamura
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Patch clamp schematic 1” PeaBrainC / CC BY-SA 4.0 (cropped)
- Ca2+ regulation and neurotransmitter release: “Cell Membrane” Blackout Sea / CC0 (cropped)
- Ca2+ channels and TRP channels: “Human N-type voltage gated calcium channel CaV2.2 7VFS” Dong Y, Gao Y, Xu S, Wang Y, Yu Z, Li Y, Li B, Yuan T, Yang B, Zhang XC, Jiang D, Huang Z, Zhao Y / CC0 (cropped)
- Mechanisms of sensors in the mouth: “Taste cells - Type I II III Receptors grey” Sagearbor / CC BY-SA 4.0 (cropped)
- Related lab (Dental and Oral Anesthesiology Lab): “Veterinary anesthesia machine close-up in Newark, New Jersey” Veterinarian Pet Alliance / CC BY 4.0 (cropped)
- Related lab (Oral Biochemistry Lab): “Lab technitian looking through the microscope while adjusting coarse knob” Shixart1985 / CC BY 2.0 (cropped)
- Related lab (Oral Physiology Lab): “Adherent cells of Capsaspora owczarzaki (filasterea)” Multicellgenome Lab / CC BY 2.0 (cropped)
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