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Organ Anatomy Lab
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An anatomy lab that explores neurological and immune diseases through the actions of lipids.
AboutAbout the lab
Exploring neurological and immune diseases through the actions of lipids
The Organ Anatomy lab studies how changes in lipid balance inside and outside cells alter the functions of neural and immune cells.
Focusing on fatty acid-binding proteins (FABPs), which carry fatty acids within cells, it investigates the mechanisms underlying neurological diseases, inflammatory diseases, and tumors.
The research uses mice and cultured cells.
Key terms
- Fatty acid-binding protein
- A protein that binds fatty acids and carries them within cells. Abbreviated as FABP, and there are several types
- Epigenome
- A mechanism that regulates how genes are read without changing the DNA sequence
- Glioblastoma
- A type of malignant brain tumor, regarded as the most difficult to treat among malignant brain tumors
- Regulatory T cell
- A T cell that suppresses immune activity. When it gathers around a tumor, it weakens the immune attack
ResearchResearch themes
The lab investigates how lipids alter the functions of cells in the nervous and immune systems. By elucidating the effects of lipids on the body, it hopes to contribute to understanding the pathology of neurological and inflammatory diseases and to developing preventive measures and treatments.
*Illustrative imageUndernutrition in Early Pregnancy and Schizophrenia
The lab created a model mouse undernourished in early pregnancy and showed that male offspring exhibit brain and behavioral changes resembling schizophrenia. It has also shown that epigenetic changes underlie these effects.
*Illustrative imageImmune Responses During Pregnancy and Offspring Brain Development
The lab administered G-CSF, an immune factor that increases with the maternal immune response during pregnancy, to pregnant mice and examined the effects on the offspring's brains. The proportion of immature synapses increased in the prefrontal cortex, and changes in social behavior were also observed later in life.
*Illustrative imageGlioblastoma Growth and FABP7
In IDH1-wild-type glioblastoma cells, the lab showed that FABP7 is abundant in the nucleus and regulates proliferation through the function of caveolae in the cell membrane. Therapeutic strategies targeting lipid metabolism in the nucleus are expected.
*Illustrative imageCurcumin Analogs and Tumor Immunity
The lab showed that GO-Y030, a compound similar to curcumin, alters mTOR signaling in regulatory T cells that gather around tumors and interferes with their immunosuppressive function. It also indicates the possibility of enhancing the effect of anti-PD-1 antibodies.
MembersFaculty
The members of the Organ Anatomy lab consist of faculty, part-time lecturers, technical staff, administrative staff, and doctoral, master's, and undergraduate students.As of 2026
- ProfessorYuji Owada
- Associate ProfessorMotoko Maekawa
- LecturerHirofumi Miyazaki
- Assistant ProfessorHinako Kirikae
- Assistant ProfessorHongbo Wang
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Biology laboratory - Japan - May 2015” Jun Seita from Palo Alto, CA, U.S. / CC BY 2.0 (cropped)
- Undernutrition in Early Pregnancy and Schizophrenia: “Balanced Food” Giovani Gio / CC BY-SA 4.0 (cropped)
- Immune Responses During Pregnancy and Offspring Brain Development: “Organs of the Immune System by AIDS.gov-es” AIDS.gov / CC BY 4.0 (cropped)
- Glioblastoma Growth and FABP7: “Cell Membrane” Blackout Sea / CC0 (cropped)
- Curcumin Analogs and Tumor Immunity: “Turmeric Powder on a Spoon - Black Background” formulatehealth / CC BY 2.0 (cropped)
- Related lab (Environmental Medicine Lab): “Disposable Pipette Tips in Laboratory Tip Boxes 02” Gannu03 / CC BY-SA 4.0 (cropped)
- Related lab (Medical Biochemistry Lab): “Pipette de laboratoire sur fond blanc au Bénin 03” Adoscam / CC BY-SA 4.0 (cropped)
- Related lab (Genome Infrastructure Development Lab (Tohoku Medical Megabank Organization)): “DNA Visual Representation of Double-Helix” 作者不詳 / Public domain (cropped)
- Related lab (Oxygen Medicine Lab (Affiliated Center for Innovative Applied Medicine)): “In the Biochemistry Laboratory” Tristan Ferne from UK / CC BY 2.0 (cropped)
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