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Cancer Medical Science / Cancer Molecular Regulation Lab (Miyagi Cancer Center)
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A lab that explores how cancer works through genome analysis and links the findings to clinical care.
AboutAbout the lab
Identifying genomic abnormalities to contribute to cancer care
The Cancer Molecular Regulation Lab is based at the research institute of Miyagi Cancer Center, where it conducts research that identifies genomic abnormalities in cancer and contributes to cancer care.
Cancer is a disease that arises when the genetic information written in the genome is altered in some of the body's cells.
Using next-generation sequencers, the lab examines the characteristics of each patient's cancer with technology that detects genomic mutations that cause cancer all at once.
Because abnormalities in the process by which chromosomes are correctly segregated during cell division are involved in carcinogenesis, the lab also studies the molecular mechanisms of this process.
Key terms
- Next-generation sequencer
- An instrument that can analyze billions of DNA sequences at once
- Liquid biopsy
- A method of performing genomic diagnosis of cancer using blood instead of cancer tissue
- Separase
- An enzyme that triggers the separation of chromosomes during cell division
ResearchResearch themes
Cancer arises when the genetic information in a cell's genome is altered. The lab pursues two lines of research: applying technology that detects genomic abnormalities in cancer to clinical care, and studying the molecular mechanisms by which cancer develops.
*Illustrative imageResearch and Development to Support Cancer Genomic Medicine
The lab develops liquid biopsy, which examines the cancer genome using blood, technology for analyzing and interpreting the results of gene panel testing, and databases, along with new analytical methods.
*Illustrative imageElucidating the Molecular Mechanisms of Carcinogenesis
The lab focuses on separase, an enzyme that triggers the separation of chromosomes. It examines DNA repair abnormalities seen in clinical cancer specimens through methods such as mutational signature analysis of cancer cells.
MembersFaculty
The members of the Carcinogenesis Control Research Department consist of the department head, senior researchers, researchers, doctoral students, collaborative researchers, and project researchers.
- ProfessorJun Yasuda
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Microbial culture flasks-set” Lilly_M / CC BY-SA 3.0 (cropped)
- Research and Development to Support Cancer Genomic Medicine: “Blood Collection Tube 02” AfroBrazilian / CC BY-SA 3.0 (cropped)
- Elucidating the Molecular Mechanisms of Carcinogenesis: “Breast cancer cell (2)” Unknown photographer / Public domain (cropped)
- Related lab (Molecular Oncology Lab (Institute of Development, Aging and Cancer)): “Olympus-BX61-fluorescence microscope” Masur / CC BY-SA 3.0 (cropped)
- Related lab (Tumor Biology Lab (Institute of Development, Aging and Cancer)): “Bacterial cell culture on agar plate ( DNA double helix conformation)” Syed Sajidul Islam / CC BY-SA 4.0 (cropped)
- Related lab (Investigative Pathology Lab): “DNBSEQ-T7” RPSkokie / CC BY-SA 4.0 (cropped)
- Related lab (Biodefense Lab (Institute of Development, Aging and Cancer)): “Flow cytometry scheme” Kwz at Polish Wikipedia / CC BY-SA 3.0 (cropped)
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