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Cell Histology Lab
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A lab that studies regenerative medicine centered on Muse cells, pluripotent stem cells found in the body.
AboutAbout the lab
Regenerative medicine built around Muse cells
The Cell Histology Lab conducts research in regenerative medicine centered on Muse cells, a novel type of pluripotent stem cell.
Muse cells are stem cells found in the mesenchymal tissues of adult humans that can differentiate into various types of cells, and they were discovered by this lab.
Because these cells can be obtained from adults, are non-tumorigenic, and have a broad capacity for tissue repair, they are expected to be applied to a wide range of diseases.
The lab works on both basic analysis and application to regenerative medicine.
Key terms
- Pluripotent stem cell
- A stem cell that can differentiate into many types of cells.
- Mesenchymal tissue
- Tissues such as bone marrow, skin, and fat. They contain mesenchymal cells such as bone, cartilage, and fat cells.
- Differentiation induction
- Manipulating stem cells to turn them into a desired type of cell.
NewsLab news
A medical student won the Best Presentation Award for an oral presentation at the 14th Summer Retreat
A medical student won an Outstanding Presentation Award at the Basic Medical Research Training Presentation Session
ResearchResearch themes
The lab conducts regenerative medicine research centered on Muse cells, a new type of pluripotent stem cell that exists within the living body. It pursues basic analysis and applied research toward regenerative medicine for a variety of diseases, both in Japan and abroad.
*Illustrative imageDiscovery and characteristics of Muse cells
The lab found pluripotent stem cells in mesenchymal tissues such as the skin and bone marrow of adult humans and named them Muse cells. A single cell can differentiate into various types of cells, and because they exist naturally in the body, they do not show tumorigenic proliferation.
*Illustrative imageRepairing tissue by administration without inducing differentiation
ES cells and iPS cells must first be induced to differentiate into the target cells, but Muse cells can be collected and administered into the body as they are. They recognize the damaged site, engraft there, and spontaneously differentiate into cells suited to the tissue.
*Illustrative imageBasic research and clinical application of Muse cells
The lab pursues basic research on their developmental origin, the factors that control their function and dynamics, the microRNA expression system, and the control of proliferative capacity. It also conducts research toward applying them in regenerative medicine for myocardial infarction, liver disease, cerebral infarction, nerve injury, diabetes, and sensory organ disorders.
MembersFaculty
The lab's members consist of faculty, postdoctoral researchers, doctoral students, School of Medicine students, and technical assistants.As of 2026
- ProfessorMari Dezawa
- LecturerShohei Wakao
- Assistant ProfessorYoshihiro Kushida
- Assistant ProfessorYasumasa Kuroda
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Pile of culture flask ( )” Jean-Etienne Minh-Duy Poirrier from USA / CC BY-SA 2.0 (cropped)
- Discovery and characteristics of Muse cells: “Neural progenitor colony” M. Oktar Guloglu / CC BY-SA 4.0 (cropped)
- Repairing tissue by administration without inducing differentiation: “Scientist checks cell culture flask on microscope” Peter Saxon / CC BY-SA 4.0 (cropped)
- Basic research and clinical application of Muse cells: “Binder CB 210 incubator interior” Shinryuu / Public domain (cropped)
- Related lab (Radiation Biology Lab): “LinearAccelerator” ja:User:Martin~jawiki / CC BY-SA 3.0 (cropped)
- Related lab (Stem Cell Medicine Lab): “Onion cells under the fluorescence microscope 2” Kateryna Kot / CC BY-SA 4.0 (cropped)
- Related lab (Molecular Oncology Lab (Institute of Development, Aging and Cancer)): “Olympus-BX61-fluorescence microscope” Masur / CC BY-SA 3.0 (cropped)
- Related lab (Neurology Lab): “PET MRI Scanner (NIH BioArt )” Courtesy of NIAID Malcolm Houston / Public domain (cropped)
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