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Cancer Medical Science / Tumor Pathology Lab (Miyagi Cancer Center)
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The lab works on predicting the effects of cancer drugs through pathological diagnosis.
AboutAbout the lab
Reading how a drug will work through diagnosis, before treatment.
The Cancer Medical Science / Tumor Pathology Lab (Miyagi Cancer Center) works, from the standpoint of pathological diagnosis, on predicting the effects of therapeutic drugs before treatment begins.
For immune checkpoint inhibitors, each drug has its own set of diagnostic assays, which makes the diagnostic procedures complicated and is considered to cause many problems.
The lab believes that better diagnostic biomarkers and companion diagnostics that can be used across organs would help avoid this confusion.
The lab's web page explains that the Tissue Bank Center is responsible for verifying the quality and accuracy of the specimens it stores.
Key terms
- Immune checkpoint inhibitor
- A drug that releases the brakes on the immune system, making it easier for immune cells to attack cancer cells.
- Companion diagnostic
- A test that determines, before treatment, whether a specific drug is likely to be effective.
- Tissue bank
- A system that stores tissue obtained from patients so that it can be used for medical care and research.
- FFPE
- Formalin-fixed, paraffin-embedded tissue: a tissue specimen fixed in formalin and embedded in paraffin for preservation.
ResearchResearch themes
Pathological diagnosis plays a role in predicting drug effects before treatment and contributing to decisions about treatment plans. The lab's web page describes the diagnostic challenges involved and the quality verification carried out by the Tissue Bank Center.
*Illustrative imageCompanion diagnostics that work across organs
For immune checkpoint inhibitors, the diagnostic assay differs from drug to drug and the cells to be evaluated differ from organ to organ, which is said to place a heavy burden on hospitals and pathology departments. Companion diagnostics that can be used across organs are needed.
*Illustrative imageTesting to verify the quality of tissue bank specimens
The Tissue Bank Center is responsible for ensuring the quality and accuracy that support the hospital's cancer genomic medicine. It checks the quality of stored fresh-frozen specimens by electrophoresis, and of FFPE specimens by extracting RNA and performing RT-PCR.
MembersFaculty
- ProfessorIkuro Sato
- Associate ProfessorShigemi Ito
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Histology laboratory (Reeve 069429), National Museum of Health and Medicine ( )” National Museum of Health and Medicine / CC BY 2.0 (cropped)
- Companion diagnostics that work across organs: “Histological section of small intestine epithelial tissue, zoom” Otávio Astor Vaz Costa / CC BY 4.0 (cropped)
- Testing to verify the quality of tissue bank specimens: “Gel electrophoresis apparatus demonstration” Ajay Kumar Chaurasiya / CC BY-SA 4.0 (cropped)
- Related lab (Precision Ophthalmic Medicine Development Lab (Affiliated Center for Innovative Applied Medicine)): “Consultation des yeux A l'hôpital Laquintinie de Douala 16” Destiny Deffo / CC BY-SA 4.0 (cropped)
- Related lab (Diagnostic Radiology Lab): “UPMCEast CTscan” daveynin from United States / CC BY 2.0 (cropped)
- Related lab (Biomarker Discovery Lab (Tohoku Medical Megabank Organization)): “Blood test samples” Fumikas Sagisavas / CC0 (cropped)
- Related lab (Investigative Pathology Lab): “DNBSEQ-T7” RPSkokie / CC BY-SA 4.0 (cropped)
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