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Comprehensive Dental Care Lab
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A comprehensive dentistry lab that designs the boundary between tooth and material to create new treatments.
AboutAbout the lab
Focusing on the interface that decides whether dental treatment succeeds.
The Comprehensive Dental Care Lab is a comprehensive dentistry lab established in 2024 as the 21st lab of the Faculty of Dental Medicine.
Comprehensive dentistry is a field that addresses oral health and disease as a whole, based on collaboration among multiple professions and integration of dental specialties.
Its research focuses on the "biointerface" that determines the success of dental treatment, combining materials science, nanotechnology, laser engineering, and regenerative medicine.
The lab emphasizes translational research that carries the results of basic research into clinical use, and is also advancing industry-academia collaboration with companies.
Key terms
- Biointerface
- The boundary where body tissues such as teeth and bone meet the materials used in treatment
- Apatite
- Crystals of calcium phosphate, the main component of teeth and bone
- Biofilm
- A film-like mass formed by bacteria gathering together. Dental plaque is one example, and drugs do not work well against it
NewsLab news
A doctoral student received the Young Investigator Outstanding Research Presentation Award from the Substitute Organs and Regenerative Medicine Research Society
Assistant Professor Nishida received the Annual Outstanding Paper Award from the Japanese Society of Conservative Dentistry
A paper from joint research with AIST was published in Surface and Interfaces (antibacterial apatite layer)
A paper from joint research with Niigata University was published in International Journal of Pharmaceutics
ResearchResearch themes
Focusing on the "biointerface" that determines the success of dental treatment, the lab pursues interface-design-based dental research that combines knowledge from different fields. In collaboration with the National Institute of Advanced Industrial Science and Technology (AIST) and labs at other universities, it works on giving new functions to tooth surfaces and dental materials.
*Illustrative imageApatite coating on tooth surfaces using lasers
In joint research with an AIST group, the lab is developing a technology that combines lasers with a biomimetic method to form an apatite layer on tooth surfaces in a short time. The aim is to load the layer with antibacterial agents and the like, and to use it in treating root caries and periodontal disease.
*Illustrative imagePhotobactericidal treatment with metal nanoclusters
In joint research with a Kansai University group, the lab studies a new photobactericidal treatment using metal nanoclusters that kill bacteria when exposed to light. It has confirmed that the white or blue LED light commonly used in dentistry can suppress biofilms of caries-causing bacteria.
*Illustrative imageAntibacterial calcium phosphate particles
In joint research with an AIST group, the lab makes microscopic calcium phosphate particles loaded with various substances and examines their antibacterial activity against oral bacteria. It also studies their use as carriers that release antibacterial drugs gradually.
*Illustrative imageGlass microparticles to prevent periodontal disease and caries
This research coats tooth surfaces with glass nanoparticles that slowly release antibacterial ions, for the prevention and treatment of periodontal disease and caries. Its effects are being confirmed in animal models of periodontal disease and in clinical research involving patients at Hokkaido University Hospital.
MembersFaculty
The lab's members are faculty, resident dentists, graduate students (including international students), visiting clinical dentists, administrative assistants, and part-time lecturers. Faculty from the Department of Comprehensive Dental Care at Hokkaido University Hospital and from the Graduate School of Biomedical Science and Engineering also join in supervision.As of 2026
- ProfessorHirofumi Miyaji
- Associate ProfessorYuichiro Matsui
- LecturerShunji Iida
- LecturerNoriyuki Takashi
- LecturerSaki Mikami
- Assistant ProfessorErika Nishida
- Assistant ProfessorKanako Shitomi
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “LightScalpel Dental CO2 Laser” Academicguru22 / CC BY-SA 4.0 (cropped)
- Apatite coating on tooth surfaces using lasers: “Oxygen tube and Pulsed Laser Deposition system at the background” Abdullahkepceoglu / CC BY-SA 4.0 (cropped)
- Photobactericidal treatment with metal nanoclusters: “Streptococcus mutans Gram” Y tambe / CC BY-SA 3.0 (cropped)
- Antibacterial calcium phosphate particles: “Microbiology techniques 2” Luis Fernando Flores LAB / CC BY-SA 4.0 (cropped)
- Glass microparticles to prevent periodontal disease and caries: “Bioactive glass” Oregon State University / CC BY-SA 2.0 (cropped)
- Related lab (Biomaterials Engineering Lab): “Hüdroksüapatiidi kristallid” Martin.Neitsov / CC BY-SA 4.0 (cropped)
- Related lab (Periodontology Lab): “Dental explorer and periodontal probe” Coronation Dental Specialty Group / CC BY-SA 3.0 (cropped)
- Related lab (Dental Public Health Lab): “A U.S. Soldier, left, assigned to Joint Task Force Jaguar gives a dental screening to a boy during Beyond the Horizon (BTH) 2013 in Metalio, El Salvador, May 18, -A-IA672-087” SPC Jacob Hamby / Public domain (cropped)
- Related lab (Radiology Lab): “Orthopantomogram of moderate crowding” Challiyan / CC BY-SA 4.0 (cropped)
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