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Biomaterials Engineering Lab
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A dental materials lab that creates materials that adhere to teeth and bone, and surfaces with fine textures.
AboutAbout the lab
Materials that suit the body, for dental care
The Biomaterials Engineering Lab researches materials used in dental treatment (biomaterials).
By imitating how the fine textures of living tissue work, it creates material surfaces to which cells attach well or that kill bacteria.
It designs “phosphorylated pullulan,” a polysaccharide derivative that adheres strongly to teeth and bone, from the molecular level, and is expanding its uses to oral care products, bone substitute materials, and more.
The lab aims to develop high-performance materials and medical devices that have not existed before.
Key terms
- Biomaterials
- Materials used inside or on the surface of the body, such as dental fillings, implants, and bone substitute materials
- Phosphorylated pullulan
- A substance made by attaching phosphate groups to pullulan, a type of polysaccharide. It adheres strongly to hard tissues such as teeth and bone
- DDS
- A mechanism for delivering a drug to where it is needed or releasing it gradually (drug delivery system)
ResearchResearch themes
The lab studies biomaterials used in dental care, focusing on phenomena at the interface where materials meet cells and tissues. Based on this understanding, it aims to develop high-performance materials and medical devices that have not existed before.
*Illustrative imageGiving surfaces function through fine textures
Imitating the micro- and nano-scale hierarchical structure of living tissue, the lab creates micro- and nano-patterns on materials to produce surfaces with strong cell adhesion and bactericidal effects. It also studies phenomena at the interface between cells and microstructured surfaces, and how they respond to applied forces such as compression, aiming for application to new implant surfaces.
*Illustrative imageMaterials that adhere to teeth and bone
Phosphorylated pullulan, molecularly designed based on the theory of adhesion to tooth structure, is a polysaccharide derivative that adheres strongly to teeth and bone. The lab is developing applications such as oral care products that deliver antibacterial substances to teeth, adhesive bone graft materials, infection-preventing implants, and DDS.
*Illustrative imageDental materials that release drugs gradually
The lab adds porous materials, whose pores can store various molecules, to dental materials as drug carriers, developing new dental materials that release drugs gradually.
MembersFaculty
- ProfessorYasuhiro Yoshida
- Associate ProfessorTsukasa Akasaka
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Hüdroksüapatiidi kristallid” Martin.Neitsov / CC BY-SA 4.0 (cropped)
- Giving surfaces function through fine textures: “Micropear” Rob Pullar / CC BY 4.0 (cropped)
- Materials that adhere to teeth and bone: “Aureobasidium pullulans” Korinna / CC BY 4.0 (cropped)
- Dental materials that release drugs gradually: “MCM-48 Mesoporous Silica Nanoparticles” Monique Tso / CC BY 4.0 (cropped)
- Related lab (口腔総合治療学教室): “LightScalpel Dental CO2 Laser” Academicguru22 / CC BY-SA 4.0 (cropped)
- Related lab (歯科保存学教室): “Composite resin fillng 3” Albert / CC BY-SA 3.0 (cropped)
- Related lab (歯科矯正学教室): “Dental braces” Sputnikcccp at English Wikipedia / CC BY-SA 3.0 (cropped)
- Related lab (生化学教室): “Rheumatology - Osteoporotic bone -- Smart-Servier” Laboratoires Servier / CC BY-SA 3.0 (cropped)
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