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Hard Tissue Microstructure Lab
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A hard tissue lab that studies the cells and tissues of bone, cartilage, and teeth under a range of microscopes.
AboutAbout the lab
Seeing what happens inside bone and teeth under the microscope
The Hard Tissue Microstructure Lab studies hard tissues such as bone, cartilage, and teeth at the level of cells and tissues.
Its topics are wide-ranging, including bone diseases such as osteoporosis, congenital skeletal abnormalities, the mechanism of mineralization, and the relationship between bone and conditions such as kidney disease and diabetes.
In addition to light and electron microscopy, the lab uses a variety of microscopy methods, including super-resolution microscopy, micro-CT, and instruments for examining the distribution of elements.
Researchers and graduate students from overseas, as well as undergraduate students, join the lab, and research is carried out with a diverse group of colleagues.
Key terms
- Hard tissue
- Body tissue that has become hard by containing minerals such as calcium, like bone and teeth
- Mineralization
- The process in which calcium phosphate crystals accumulate in a matrix such as collagen and make it hard
- Remodeling
- The process by which old bone is broken down and replaced with new bone. Through it, bone is rebuilt throughout life
NewsLab news
An Assistant Professor received the 45th Japanese Society for Bone Morphometry Young Investigator Award
A lab member received the 45th Japanese Society for Bone Morphometry Young Investigator Award
ResearchResearch themes
The lab studies hard tissues such as bone, cartilage, and teeth, mainly from the perspectives of histology and developmental biology. Using genetically modified mice and animal models of disease, it combines various microscopy methods with techniques from molecular biology and biochemistry.
*Illustrative imageCell biology of bone metabolism
Bone is constantly renewed through the interplay of osteoblasts, which form bone, osteoclasts, which resorb bone, and osteocytes, which are embedded within the bone (remodeling). The lab studies this mechanism of bone metabolism at the cellular level.
*Illustrative imageMechanisms of mineralization from microstructure
Mineralization of the bone matrix begins when crystals form inside small vesicles released by osteoblasts (matrix vesicles) and then spreads to the surrounding collagen fibers. The lab studies this process through fine structure.
*Illustrative imageHow bone, cartilage, and periodontal tissues form
In growing bone, endochondral ossification occurs, in which cartilage is replaced by bone. The alveolar bone, cementum, and periodontal ligament that support the teeth differentiate from cells of the dental follicle surrounding the tooth germ. The lab studies these mechanisms of differentiation and development.
*Illustrative imageLinks between bone and other organs
Using genetically modified mice and animal models of disease, the lab studies connections with other organs that regulate bone metabolism (organ crosstalk), such as the relationship between kidney disease or diabetes and bone metabolism.
MembersFaculty
The members of the Hard Tissue Microstructure Lab are faculty, graduate students, researchers and graduate students from overseas, and undergraduate students.
- ProfessorNorio Amizuka
- Associate ProfessorTomoka Hasegawa
- Assistant ProfessorHiromi Hongo
- Assistant ProfessorMako Sakakibara
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Bone histomorphometry” Jbakalovic / CC BY 4.0 (cropped)
- Cell biology of bone metabolism: “Bone regeneration - Bone remodeling cycle III - Osteoclasts Monocytes Pre-osteoblasts etc -- Smart-Servier (cropped)” Laboratoires Servier / CC BY-SA 3.0 (cropped)
- Mechanisms of mineralization from microstructure: “Bertazzo S - SEM deproteined bone - wistar rat - x10k” Sbertazzo / CC BY-SA 3.0 (cropped)
- How bone, cartilage, and periodontal tissues form: “Proximal tibia Masson Goldner Trikrom rabbit 600x growth zone” Jn20 Jeppe Achton Nielsen / CC BY-SA 3.0 (cropped)
- Links between bone and other organs: “Stained microscope slide” Waughd / CC BY-SA 4.0 (cropped)
- Related lab (生化学教室): “Rheumatology - Osteoporotic bone -- Smart-Servier” Laboratoires Servier / CC BY-SA 3.0 (cropped)
- Related lab (微生物学教室): “Microscope view of Candida albicans” Korinna / CC BY 4.0 (cropped)
- Related lab (薬理学教室): “Spongy bone - Trabecular bone -- Smart-Servier” Laboratoires Servier / CC BY-SA 3.0 (cropped)
- Related lab (口腔機能解剖学教室): “Gl.submandibularis” Rollroboter / CC BY-SA 4.0 (cropped)
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