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Senkenji Lab
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The lab investigates the mechanisms of cellular senescence and chronic inflammation to explore new treatments.
AboutAbout the lab
Understanding the body's built-in health mechanisms from the cellular level
The Senkenji Lab studies, at the molecular and cellular level, the mechanisms that keep the body healthy.
Its focus is cellular senescence, a phenomenon known to be involved in chronic inflammation and degeneration in many organs while also playing an important role in tissue regeneration.
The lab investigates the mechanisms of diseases such as autoimmune diseases, skeletal muscle diseases, and depression, and works to develop new treatments that combine rehabilitation and drugs.
The lab is recruiting graduate students and welcomes lab visits at any time.
Key terms
- Cellular senescence
- A phenomenon in which cells stop dividing. Senescent cells may release substances that cause inflammation
- Chronic inflammation
- A condition in which mild inflammation persists for a long time. It underlies many different diseases
- Autoimmune disease
- A disease in which the immune system, which normally protects the body, mistakenly attacks the body's own tissues
- Regenerative medicine
- Medicine that uses cells and other materials to restore the function of damaged tissues or organs
NewsLab news
Doctoral and master's students received Outstanding Presentation Awards at the Japanese Society of Inflammation and Regeneration
A doctoral student received the Clinical Immunology Trainee Award at FOCIS 2026
A master's student received an Outstanding Oral Presentation Award at the Annual Meeting of the Japanese Orthopaedic Association
ResearchResearch themes
The lab examines the mechanisms of various diseases, focusing on how cellular senescence relates to chronic inflammation and tissue regeneration. Through combinations with rehabilitation and drugs, as well as regenerative medicine, it explores new treatments that suppress chronic inflammation.
*Illustrative imageMechanisms of cellular senescence and chronic inflammation
Using molecular and cell biology methods, the lab investigates the mechanisms of diseases that cause chronic inflammation, such as autoimmune diseases, depression, and diabetes, in relation to cellular senescence.
*Illustrative imageTissue regenerative rehabilitation
The lab explains phenomena induced by rehabilitation in terms of cellular and molecular activity, and explores ways to suppress chronic inflammation by combining rehabilitation with drug treatment.
*Illustrative imageMesenchymal stromal cell therapy for chronic inflammation
Applying the concept of regenerative medicine, the lab explores cell therapies that suppress chronic inflammation. In a mouse model of systemic lupus erythematosus, it has shown that cell therapy improves dermatitis.
MembersFaculty
Members of the Senkenji Lab consist of faculty, postdoctoral researchers, doctoral and master's students, and technical assistants.As of 2026
- ProfessorTakako Senkenji
- LecturerMaki Miyajima
- Assistant ProfessorKana Umamichi
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “MSCs D21” MFT29 / CC BY-SA 4.0 (cropped)
- Mechanisms of cellular senescence and chronic inflammation: “SABG MEFs” Y tambe / CC BY-SA 3.0 (cropped)
- Tissue regenerative rehabilitation: “Myogenesis - ISRO (jsc2025e039327)” NASA Johnson Space Center / Public domain (cropped)
- Mesenchymal stromal cell therapy for chronic inflammation: “MSCs D7 (2)” MFT29 / CC BY-SA 4.0 (cropped)
- Related lab (Musculoskeletal Disorders Lab): “Osteoarthritis on X-ray” James Heilman, MD / CC BY-SA 4.0 (cropped)
- Related lab (Pathological and Immunological Laboratory Science Lab): “Renal corpuscle” Ed Uthman (Pathologist) / CC BY-SA 2.0 (cropped)
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