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Pathological and Immunological Laboratory Science Lab
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A lab that investigates the causes and pathology of autoimmune diseases using methods from pathology and immunology.
AboutAbout the lab
Tackling hard-to-treat diseases from both pathology and immunology.
The Pathological and Immunological Laboratory Science Lab uses methods from pathology and immunology to clarify the causes of diseases and to develop ways of evaluating disease conditions.
For hard-to-treat diseases such as autoimmune diseases, the lab aims to create new evaluation methods and new treatments.
The lab began in 2008 as the Pathological Laboratory Science Lab, and in 2015 it merged with the Immunological Laboratory Science Lab to become the present lab.
The faculty members also teach pathological laboratory science and immunological laboratory science to undergraduate and graduate students.
Key terms
- Autoimmune disease
- A disease in which the immune system, which normally protects the body, attacks the body's own tissues
- Neutrophil
- A type of white blood cell. It acts during infections such as bacterial infection, and can also trap bacteria by releasing web-like structures
- Autoantibody
- An antibody that targets components of the body itself. ANCA and anti-GBM antibodies are examples
NewsLab news
Professor Ishizu received the Japanese Pathology Award
Lecturer Nishibata received the Faculty of Health Sciences Excellent Paper Award
Lecturer Nishibata received the Hokkaido Medical Society Research Encouragement Award
ResearchResearch themes
For hard-to-treat diseases such as autoimmune diseases, the lab aims to clarify their causes and to create new methods for evaluating disease conditions and new treatments. Focusing on ANCA and neutrophil extracellular traps (NETs), it investigates the mechanisms by which diseases such as vasculitis develop.
*Illustrative imageMechanisms of ANCA-associated vasculitis
The lab studies an inflammatory disease of small blood vessels in which autoantibodies called ANCA are produced. It has shown that a vicious cycle in which ANCA and NETs strengthen each other contributes to the onset of the disease.
*Illustrative imageAbnormalities of neutrophil extracellular traps and disease
Neutrophils release web-like structures (NETs) to trap bacteria. The lab investigates how failures in forming or breaking down NETs contribute to various diseases.
*Illustrative imageMechanisms behind the production of anti-glomerular basement membrane antibodies
In some patients with ANCA-associated vasculitis, autoantibodies against the basement membranes of the lungs and kidneys (anti-GBM antibodies) are produced. The lab studies why this happens, in relation to ANCA.
MembersFaculty
The Pathological and Immunological Laboratory Science Lab consists of faculty members, research fellows, technical assistants, and doctoral and master's students.As of 2026
- ProfessorAkihiro Ishizu
- LecturerSakiko Masuda
- LecturerYuka Nishibata
- Project Assistant ProfessorIkuma Hori
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Renal corpuscle” Ed Uthman (Pathologist) / CC BY-SA 2.0 (cropped)
- Mechanisms of ANCA-associated vasculitis: “WBC (neutrophil) at centre, numerous erythrocytes and platelets (dot like bodies) in Wright's stained peripheral blood smear (PBS) microscopy” Ajay Kumar Chaurasiya / CC BY-SA 4.0 (cropped)
- Abnormalities of neutrophil extracellular traps and disease: “Neutrophil Extracellular Trap” CHDENK / CC BY-SA 4.0 (cropped)
- Mechanisms behind the production of anti-glomerular basement membrane antibodies: “Immunofluorescence staining for IgG along glomerular capillary loops” Adel.stoyanova / CC BY-SA 4.0 (cropped)
- Related lab (Kamishima Lab): “Knee MRI T1 TSE Sagittal” Ptrump16 / CC BY-SA 4.0 (cropped)
- Related lab (Senkenji Lab): “MSCs D21” MFT29 / CC BY-SA 4.0 (cropped)
- Related lab (Cardiovascular Echo Lab): “Echocardiogram in US Navy” U.S. Air Force photo by Senior Airman Kasey Close / Public domain (cropped)
- Related lab (Social Medical Informatics Lab): “Satellite image of Hokkaido, Japan in May 2001” NASA / Public domain (cropped)
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