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Neurology Lab
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A lab that investigates the mechanisms and diagnosis of cerebellar diseases and autoimmune neurological disorders.
AboutAbout the lab
Research that learns from patients and gives back to patients
The Neurology Lab conducts research useful for the diagnosis and treatment of diseases of the brain, spinal cord, peripheral nerves, and muscles.
It works on diseases such as spinocerebellar degeneration, multiple system atrophy, multiple sclerosis, muscle diseases, and dementia.
It combines various methods, including molecules in blood and cerebrospinal fluid, brain imaging, genetic analysis, and neuropsychological testing.
In cooperation with collaborating institutions across Japan, the lab also advances patient registry studies and the discovery of new autoantibodies.
Key terms
- Spinocerebellar degeneration
- A general term for diseases in which mainly the cerebellum and the nerves connected to it gradually deteriorate, causing symptoms such as unsteadiness.
- Biomarker
- A substance contained in blood, cerebrospinal fluid, and the like that serves as an indicator of the presence or progression of a disease.
- Cohort
- A group of people with the same conditions that is gathered and followed over a long period for research.
NewsLab news
Lecturer Iwata received the 2026 Best Faculty Member Award of the Hokkaido University Faculty of Medicine
Press release on the results of a nationwide survey of autoimmune cerebellar ataxia
Assistant Professor Eguchi received the Encouragement Award (Outstanding General Presentation Award) at the 7th Annual Meeting of the Japanese Society of Medical AI
Press release on establishing the first assay in Japan for measuring KLHL11 antibodies
Associate Professor Yaguchi received the Outstanding Paper Award of the Faculty of Medicine, Graduate School of Medicine, and School of Medicine, Hokkaido University, for fiscal year 2024
ResearchResearch themes
The lab aims to diagnose neurological diseases earlier, assess their progression accurately, and lead to better treatment. It studies spinocerebellar degeneration, multiple system atrophy, multiple sclerosis, muscle diseases, autoimmune neurological disorders, and more.
*Illustrative imageSpinocerebellar degeneration
Among the spinocerebellar degenerations, in which the cerebellum and other regions deteriorate, many cases remain of unknown cause. Working with collaborating institutions across Japan, the lab aims to obtain clues useful for treatment.
*Illustrative imageRegistry study of patients with multiple system atrophy
The lab is building a cohort of patients with multiple system atrophy (MSA) living in Hokkaido to study the natural course and epidemiology of the disease.
*Illustrative imageBiomarkers of neurological diseases
For dementia, Parkinson's disease, multiple sclerosis, and other diseases, the lab searches for molecules in blood, cerebrospinal fluid, and urine that indicate disease activity and severity. It also devises new neurophysiological tests and brain imaging analysis methods and verifies their effectiveness.
*Illustrative imageMultiple sclerosis
The lab analyzes clinical data collected so far on multiple sclerosis, in which lesions appear and disappear in the brain, spinal cord, and optic nerve. It aims to identify the characteristics of patients who should be treated aggressively and of those with a favorable course.
MembersFaculty
The members of the Neurology Lab are faculty. Faculty from on-campus centers such as the Health Care Center and the Mild Cognitive Impairment Center, and from the Faculty of Health Sciences, also help supervise students.As of 2026
- ProfessorIchiro Yabe
- Associate ProfessorHiroaki Yaguchi
- Associate Professor (Health Center)Masaaki Matsushima
- Lecturer (Mild Cognitive Impairment Center)Ikuko Iwata
- Assistant ProfessorShinichi Shirai
- Assistant ProfessorHisashi Uwatoko
- Assistant Professor (Collaborative Research Center, Medical Research AI Support Division)Katsuki Eguchi
- Project Assistant ProfessorTaichi Nomura
- Project Assistant ProfessorAkihiko Kudo
- Project Assistant Professor (Clinical Research and Development Center)Shintaro Fujii
- Associate Professor (Faculty of Health Sciences)Mika Otsuki
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Neurological tools” Ali Raheem / CC BY-SA 3.0 (cropped)
- Spinocerebellar degeneration: “SCA Cerebellar Degeneration Sag T1” Argarrett / CC BY-SA 4.0 (cropped)
- Registry study of patients with multiple system atrophy: “MSA aSynuclein” Jensflorian / CC BY-SA 3.0 (cropped)
- Biomarkers of neurological diseases: “4 vials of human cerebrospinal fluid” James Heilman, MD / CC BY 3.0 (cropped)
- Multiple sclerosis: “Axial MRI scans of a person with multiple sclerosis ( )” NIH Image Gallery from Bethesda, Maryland, USA / Public domain (cropped)
- Related lab (Respiratory and Circulatory Innovative Research Lab): “CTA Chest With Massive Pulmonary Embolism and Complete Occlusion” Rvahudson / CC BY-SA 4.0 (cropped)
- Related lab (Cancer Genomic Medicine Lab): “DNA Nanoball sequencing flow cell” Suspencewl / CC0 (cropped)
- Related lab (Psychiatry Lab): “DTI-sagittal-fibers” Thomas Schultz / CC BY-SA 3.0 (cropped)
- Related lab (Neurosurgery Lab): “Circle of Willis - MRI, MIP - Anterior projection” Ceccomaster / CC BY-SA 3.0 (cropped)
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