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Neurosurgery Lab
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A lab that tackles diseases of the brain and spinal cord through surgery and regenerative medicine.
AboutAbout the lab
From daily clinical practice to the medicine of the future
The Neurosurgery Lab works on surgical treatment of diseases of the brain, spinal cord, and peripheral nerves, and on research in these areas.
With surgical treatment of cerebrovascular disease, brain tumors, and spinal cord and spine disorders as its three pillars, the lab also has specialist staff in endovascular treatment and functional neurosurgery.
Based on insights gained from daily clinical practice, the lab carries out both basic and clinical research.
The lab invites medical students interested in neurosurgery or related fields to visit.
Key terms
- Moyamoya disease
- A disease in which the large arteries of the brain gradually narrow while fine vessels develop like a net in their place. It is more common in people of East Asia.
- Mesenchymal stem cells
- Cells found in places such as bone marrow that can turn into various cell types, including bone and fat. They are used in regenerative medicine.
- PET
- An examination that uses radioactive tracers to image metabolism, such as of glucose, inside the body. It stands for positron emission tomography.
NewsLab news
Lecturer Osanai received the Society Award at The Mt. Fuji workshop on CVD
Lecturer Kawabori received the Hokkaido University President's Award for Research and Education
A graduate student received the Excellence Award at the Hokkaido Society 5.0 Future Creation Workshop
Lecturer Kawabori received the Award of the Japanese Society of Cerebral Blood Flow and Metabolism
Received the top award in the Outstanding Course category of the Hokkaido University Faculty of Medicine Clinical Clerkship 2023 (all departments)
ResearchResearch themes
Building on insights from daily clinical practice, the lab conducts research that leads to advances in neurosurgical care. It pursues basic research using genes and stem cells, and clinical research on cerebrovascular disease, brain tumors, and more.
*Illustrative imageInvestigating the cause of moyamoya disease
With patients' cooperation, the lab collects clinical information and samples such as blood, and analyzes genes, the epigenome, and proteins. It also conducts research using iPS cells and international collaborations, aiming to clarify the mechanisms of onset and the factors involved in the course of the disease.
*Illustrative imageRegenerating the brain and spinal cord with bone marrow cells
Using animal models of cerebral infarction, intracerebral hemorrhage, spinal cord injury, and dementia, the lab studies whether function can be restored with stem cells, scaffold materials for them, and substances secreted by the cells. For practical application, it is also developing an automated cell culture device.
*Illustrative imageTreating the spinal cord with stem cell sheets
The lab studies transplanting sheets of cells made from bone marrow mesenchymal stem cells into rats with spinal cord injury. It has also started research aiming to develop fetal surgery that uses amniotic fluid stem cell sheets to treat spinal cord diseases before birth.
*Illustrative imageInterpreting PET images of brain tumors at the molecular level
The lab combines tumor specimens obtained at surgery with the glucose and amino acid metabolism and hypoxia of tumors seen on PET, and analyzes them with molecular biology methods. It searches for molecular markers that predict the clinical course and molecules that could serve as therapeutic targets.
MembersFaculty
The members of the Neurosurgery Lab are faculty, hospital physicians, doctoral students, and residents in specialty training. Physicians from the Department of Neurosurgery at Hokkaido University Hospital also help supervise students.As of 2026
- ProfessorMiki Fujimura
- LecturerShigeru Yamaguchi
- LecturerToshiya Osanai
- LecturerTaku Sugiyama
- LecturerMasahito Kawabori
- Clinical LecturerMotoyuki Iwasaki
- Assistant ProfessorYukitomo Ishi
- Assistant ProfessorHaruto Uchino
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Circle of Willis - MRI, MIP - Anterior projection” Ceccomaster / CC BY-SA 3.0 (cropped)
- Investigating the cause of moyamoya disease: “Moyamoya02” Dr Frank Gaillard / CC BY 3.0 (cropped)
- Regenerating the brain and spinal cord with bone marrow cells: “Human bone marrow derived MSCs” Chinmaya Mahapatra / CC BY-SA 3.0 (cropped)
- Treating the spinal cord with stem cell sheets: “Spinal cord (26 2 16) Rat; cross-section” Doc. RNDr. Josef Reischig, CSc. / CC BY-SA 3.0 (cropped)
- Interpreting PET images of brain tumors at the molecular level: “Glioblastoma multiforme - MRT T1KM ax” Hellerhoff / CC BY-SA 3.0 (cropped)
- Related lab (Ophthalmology Lab): “Fundus photograph-normal retina EDA06” 作者不詳 / Public domain (cropped)
- Related lab (Neurology Lab): “Neurological tools” Ali Raheem / CC BY-SA 3.0 (cropped)
- Related lab (Orthopaedic Surgery Lab): “Hip replacement Image 3684-PH” X-ray Image ID: 3684. Photographer: Unknown. / Public domain (cropped)
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