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Cardiovascular Medicine Lab
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The lab explores the mechanisms of arrhythmia, heart failure, and ischemia through both clinical and basic research.
AboutAbout the lab
Be ambitious at a center of learning in the north
The lab studies the mechanisms and treatments of heart and blood vessel diseases, such as ischemia, heart failure, and arrhythmia.
It combines questions that arise from clinical practice with basic research that digs down to the molecular and genetic level.
Hokkaido University Hospital is the only heart transplant facility in Hokkaido, and it provides advanced medical care such as catheter-based treatment and treatment of severe heart failure.
At the weekly research conference, graduate students present the progress of their research, and students are free to attend.
Key terms
- Optical mapping
- A method that uses a fluorescent dye to image how electrical activity spreads across the surface of the heart
- Biobank
- A system that collects and stores patients' samples, such as blood, together with clinical information so that they can be used for research
- TAVI
- Transcatheter aortic valve implantation. A treatment that replaces a damaged aortic valve with an artificial valve using a catheter, without opening the chest widely
NewsLab news
Original article by a graduate student and an Associate Professor published in JACC: Advances
Case report by a graduate student and a Lecturer published in European Heart Journal-Case Report
Original article by a graduate student and an Associate Professor published in Journal of Cardiac Failure
Original article published in JACC: Asia
Case report by graduate students and others published in JACC: Case Reports
ResearchResearch themes
Centered on cardiovascular diseases such as ischemia, heart failure, and arrhythmia, the lab links clinical questions with basic research, aiming to clarify how diseases arise and to develop treatments. Through multicenter collaboration with affiliated hospitals in Hokkaido, it is also building a large-scale heart failure database unique to Japan.
*Illustrative imageMechanisms of arrhythmia
The lab studies ventricular and atrial arrhythmias using both basic and clinical approaches. Using optical mapping and patch clamp, it examines the electrical activity of the heart and of cardiomyocytes, and it works on how arrhythmias arise in hypertrophied hearts and diabetic hearts, as well as on analyses using optogenetics.
*Illustrative imageHeart failure and cardiomyopathy
Aiming at personalized medicine for heart failure, the lab is building a heart failure registry and biobank in cooperation with institutions inside and outside Hokkaido. It also conducts hemodynamic studies combining exercise-stress catheterization with echocardiography, research using cardiac MRI jointly with the Department of Diagnostic Imaging, and research on inflammation-related cardiomyopathies such as cardiac sarcoidosis.
*Illustrative imageCoronary artery disease and valvular heart disease
The lab conducts research on ischemic heart disease using intracoronary imaging (IVUS and OCT) and analyzes coronary artery disease that develops after heart transplantation. It is also advancing research on catheter-based treatments such as TAVI for aortic valve stenosis.
MembersFaculty
The lab's members consist of faculty, hospital staff physicians, doctoral students, and visiting researchers. The faculty includes clinical lecturers at Hokkaido University Hospital.As of 2026
- ProfessorToshihisa Anzai
- Associate ProfessorToshiyuki Nagai
- LecturerTaro Koya
- LecturerAtsushi Tada
- Project LecturerKiwamu Kamiya
- Assistant ProfessorSuguru Ishizaka
- Clinical LecturerYuta Kobayashi
- Assistant ProfessorHaruki Tamaki
- Project Assistant ProfessorMotoki Nakao
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Dresden, Deutsches Hygiene-Museum, anatomisches Modell, Herz” Dguendel / CC BY 4.0 (cropped)
- Mechanisms of arrhythmia: “Microphotograph of connexin 43 distribution in the rat myocardium” Veronika Gurianova / CC BY-SA 4.0 (cropped)
- Heart failure and cardiomyopathy: “Cardiomr dcm” MBq / CC0 (cropped)
- Coronary artery disease and valvular heart disease: “Ha1” Bleiglass / CC BY-SA 3.0 (cropped)
- Related lab (消化器内科学): “Endoscopy” Linda Bartlett / Public domain (cropped)
- Related lab (神経内科学): “Neurological tools” Ali Raheem / CC BY-SA 3.0 (cropped)
- Related lab (産婦人科学): “Placenta (265 26) Section of human placenta” Doc. RNDr. Josef Reischig, CSc. / CC BY-SA 3.0 (cropped)
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