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Cancer Control Lab
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The lab uses Drosophila and other models to explore how cancer develops and to find new therapeutic drugs.
AboutAbout the lab
Making cancer a controllable disease.
The lab aims to elucidate how cancer develops and to develop drugs to treat it.
Using a variety of materials, including human specimens, Drosophila, and mice, it carries out research in genetics, biochemistry, molecular biology, and drug discovery science.
Recently, the lab has been focusing on pancreatic cancer, for which treatment options are extremely limited.
Lab visits are accepted, and the lab welcomes people who want to do research in the master's or doctoral program.
Key terms
- Drosophila
- Drosophila (fruit fly): a fly a few millimeters long. Its genes are very similar to those of humans and a new generation is born in about 10 days, so it is used in disease research.
- Phosphorylation
- Phosphorylation: the attachment of a small molecule called a phosphate to a protein. It acts as a switch for protein function.
- Therapeutic target
- Therapeutic target: a molecule that a drug aims to inhibit or enhance. In cancer, many targets are proteins involved in processes such as proliferation.
NewsLab news
A doctoral student identifies therapeutic targets for each genetic mutation pattern of pancreatic cancer and publishes the results in Cancer Science
A doctoral student wins a poster award at the 12th IGM Research Meeting
A doctoral student identifies a new therapeutic target for pancreatic cancer and publishes the results in Molecular Therapy
Assistant Professor Yamamura and colleagues publish in Inflammatory Bowel Diseases on the relationship between ulcerative colitis, vitamin B3 metabolism, and gut bacteria
Assistant Professor Yamamura and colleagues, jointly with the Faculty of Medicine, clarify the relationship between stool components, gut bacteria, and obesity
ResearchResearch themes
To establish strategies for preventing and treating cancer, the lab works on two goals: elucidating how cancer develops and developing candidate lead compounds for new therapeutic drugs. It combines Drosophila with experiments using cultured human cells and mice, and focuses in particular on pancreatic cancer, an intractable cancer.
*Illustrative imageMarkers for identifying malignant progression of colorectal cancer
The lab focuses on phosphorylation of the protein TRIO, which is involved in how colorectal tumors progress to malignant cancer. Using this as a marker, it is working toward practical use of a test (immunohistochemistry, which stains tissue with antibodies) that distinguishes patient prognosis and guides treatment decisions.
*Illustrative imageSearching for pancreatic cancer drugs using flies
The lab creates Drosophila that reproduce the genetic abnormalities seen in human pancreatic cancer and searches for new therapeutic targets through a comprehensive experiment examining all kinases. It then tests drug combinations aimed at the candidate targets in flies and mice, and is advancing the development of more effective drugs for pancreatic cancer.
MembersFaculty
The members of the Cancer Control Lab are faculty, doctoral, master's, and undergraduate students, visiting fellows and visiting students, research support staff, technical assistants, and visiting professors.As of 2026
- ProfessorMasahiro Sonoshita
- Assistant ProfessorRyodai Yamamura
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Drosophila melanogaster laboratory culture-vial” Masur / CC BY-SA 4.0 (cropped)
- Markers for identifying malignant progression of colorectal cancer: “Colorectal adenocarcinoma - pT2, intermed. mag” CoRus13 / CC BY-SA 4.0 (cropped)
- Searching for pancreatic cancer drugs using flies: “Adenocarcinoma of Pancreas, FNA ( )” Ed Uthman from Houston, TX, USA / CC BY 2.0 (cropped)
- Related lab (Tumor Pathology Lab): “Histopathology of prostate adenocarcinoma involving adipose tissue” Mikael Häggström, M.D. / CC0 (cropped)
- Related lab (Cancer Genomic Medicine Lab): “DNA Nanoball sequencing flow cell” Suspencewl / CC0 (cropped)
- Related lab (Obstetrics and Gynecology Lab): “Placenta (265 26) Section of human placenta” Doc. RNDr. Josef Reischig, CSc. / CC BY-SA 3.0 (cropped)
- Related lab (Breast Surgery Lab): “Mammogram showing normal dense breasts” Unknown photographer / Public domain (cropped)
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