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Ota Lab
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The lab creates new measurement methods using light and fluid technologies to decode life.
AboutAbout the lab
Decoding life through measurement
Ota Lab develops next-generation biotechnology that pursues the value of information.
By combining optical, electrical, microfluidic, and soft-material technologies with information science and synthetic biology, the lab creates new measurement mechanisms.
Its research targets include molecules, bacteria, cells, extracellular vesicles, and organoids, with the aim of discovering phenomena in biomedical science and biophysics and elucidating their mechanisms.
The members include hardware experts in optics and fluidics as well as experts in biology and chemistry, and they advance research through collaboration across fields.
Key terms
- Microfluidics
- A technology for handling very small amounts of liquid by flowing it through channels as thin as a human hair
- Organoid
- A small cluster of cells grown from stem cells or similar sources that has a shape and functions resembling those of an organ
- Evolutionary molecular engineering
- A method for creating molecules with desired functions by repeatedly selecting the best ones from a large number of variants
- Label-free
- Measuring cells or molecules as they are, without attaching markers such as fluorescent dyes
NewsLab news
Developed a technology to write optical barcodes onto tiny beads and produce them in large quantities
In collaboration with Chiba University and others, developed a method to produce large quantities of uniform cell-containing capsules in a short time
ResearchResearch themes
Through the development of new technologies and the proposal of new concepts, the lab aims to open up new research in biomedical science and biophysics and to make an impact on the real world. It values the idea of connecting technologies from different fields to create solutions suited to each purpose.
*Illustrative imageDevelopment of high-speed biotechnology
Using technologies from optics, fluidics, materials, and chemistry, the lab builds original measurement systems, including high-speed 3D imaging flow cytometry, label-free analysis that requires no markers, and droplet sorting. It has also developed technology that links different types of measurement data, such as imaging and omics, for each individual cell.
*Illustrative imageBiomedical research and pharmaceutical applications
Using its original high-speed measurement, the lab tackles problems in immunology, hematologic malignancies, microbiology, infection, and stem cells. It builds AI models that predict how living systems respond to diverse stimuli, aiming to realize next-generation AI-based diagnosis of cell morphology.
*Illustrative imageNext-generation evolutionary molecular engineering
Through collaborative research, the lab combines the world's fastest droplet sorting technology and hydrogel technology with evolutionary molecular engineering and synthetic biology, aiming to develop platforms for creating functional proteins, bacteria, and cells. It also makes use of machine learning and data science.
*Illustrative imageAI-driven biophysics
Using data obtained from high-speed multimodal measurement, the lab takes on the challenge of discovering the physical laws by which structures inside cells give rise to function. It regards cells and intracellular structures as materials and seeks to understand their responses from the perspectives of physics and statistics.
MembersFaculty
The members of Ota Lab consist of faculty members, researchers, graduate students, technical staff, and other staff.
- ProfessorSadao OtaPublications ↗
- Assistant ProfessorAkihiro Eguchi
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Flow Cytometer (NIH BioArt 160)” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Development of high-speed biotechnology: “Combined coflow countercurrent flow focusing microfluidic emulsification schematic” Anonlizzy / CC BY 4.0 (cropped)
- Biomedical research and pharmaceutical applications: “WBC (neutrophil) at centre, numerous erythrocytes and platelets (dot like bodies) in Wright's stained peripheral blood smear (PBS) microscopy” Ajay Kumar Chaurasiya / CC BY-SA 4.0 (cropped)
- Next-generation evolutionary molecular engineering: “CSIRO ScienceImage 3567 Examining an agar dish for bacterial colonies as part of the bioremediation project” David McClenaghan, CSIRO / CC BY 3.0 (cropped)
- AI-driven biophysics: “Multicolor fluorescence image of a living HeLa cell” 8x57is / CC BY-SA 4.0 (cropped)
- Related lab (Bioanalytical Chemistry Lab): “Nikon-Inverted fluorescence microscope” ArthurLau1997 / CC BY 4.0 (cropped)
- Related lab (Kawaguchi Lab): “Normalized Linkage Heat Map” CP2000A / CC BY-SA 4.0 (cropped)
- Related lab (Protein Metabolism Lab): “Proteasome (NIH BioArt )” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Related lab (Synthetic Organic Chemistry Lab): “Rotationsverdampfer” Gmhofmann 12:13, 26. Jun. 2007 (CEST) / Public domain (cropped)
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