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Applied Immunology Lab
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The lab explores infectious diseases caused by protozoan parasites, such as leishmaniasis, from an immunological perspective.
AboutAbout the lab
Understanding infectious diseases and putting pathogens to good use.
The Applied Immunology Lab uses the methods of immunology to study protozoan diseases, which are infectious diseases caused by protozoa.
Its main targets are leishmaniasis and toxoplasmosis.
Beyond analysis of genes and cells, the lab's research takes in infected animals and patients, and the field sites where the diseases are spreading.
The lab also conducts a great deal of international collaborative research with researchers overseas.
Key terms
- Protozoa
- Single-celled organisms that behave like animals; the term here refers to those that live as parasites on other organisms and cause disease.
- Leishmaniasis
- A zoonotic infectious disease of humans and animals caused by protozoa of the genus Leishmania, transmitted when a sand fly bites and feeds on blood.
- Vector control
- Measures to prevent the spread of infection by cutting off contact between humans and the insects (vectors) that carry pathogens, or by reducing the number of those insects.
NewsLab news
Reported the effects of maternal Leishmania infection on the disease state of offspring
Reported the role played by BAFF in B-cell malignancies
Reported vertical transmission of Leishmania parasites in pregnant mice
Reported research findings on symbiotic bacteria in sand flies in Japan
ResearchResearch themes
The lab conducts a wide range of immunological research on infectious diseases caused by protozoan parasites (protozoan diseases). Its research goes beyond the analysis of genes, molecules, and cells, and is fundamentally grounded in work that also takes in infected animals, patients, and the field sites where protozoan diseases are being transmitted.
*Illustrative imageHost Defense and Immunopathology
In infectious diseases, the immune system drives out pathogens but can also cause symptoms that are harmful to the body. Using genetically modified animals and other models, the lab investigates the mechanisms behind both of these roles in protozoan diseases.
*Illustrative imageTechnologies for Diagnosis, Treatment, and Prevention
The lab develops technologies for the diagnosis, treatment, and prevention of protozoan diseases through research on searching for antigens useful for diagnosis, producing antibodies specific to pathogenic protozoa, simple diagnostic techniques, and the therapeutic effects of natural compounds.
*Illustrative imageDrug Discovery Using Pathogens
Focusing on the mechanisms by which parasites control the host's immune system, the lab regards parasites as a new resource for drug discovery. It aims to establish "parasite mimetics," an approach of searching for substances that can help overcome cancer, allergies, and other diseases.
*Illustrative imageControlling Disease-Carrying Insects
The lab studies sand flies, which transmit leishmaniasis, looking at how to distinguish species, their ecology, and the mechanisms by which they become resistant to insecticides. The aim is vector control suited to each region.
MembersFaculty
The members of the Applied Immunology Lab consist of faculty, project researchers, academic specialist staff and project specialist staff, doctoral, master's, and undergraduate students, and research students.As of 2026
- ProfessorYasuyuki GotoPublications ↗
- Associate ProfessorChizu SanjobaPublications ↗
- Assistant ProfessorHaruka MizobuchiPublications ↗
- Project Assistant ProfessorYuki ShoshiPublications ↗
- Specially Appointed Professor (Part-time)Kyoko Sawabe
- Project Associate Professor (Part-time)Mitsuko Kudo
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Leishmania major promastigotes” Abanima (ru.wikipedia) / CC BY-SA 3.0 (cropped)
- Host Defense and Immunopathology: “Leishmania donovani amastigotes in Giemsa stained smear of FNAC” Ajay Kumar Chaurasiya / CC BY-SA 4.0 (cropped)
- Technologies for Diagnosis, Treatment, and Prevention: “HIV and Syphilis Diagnostics Laboratory Workstation” Aliva Sahoo / CC BY 4.0 (cropped)
- Drug Discovery Using Pathogens: “Toxoplasma parasites (tachyzoites) in a fibroblast host cell” Morne Arin (Ksena Longrin) / CC BY 4.0 (cropped)
- Controlling Disease-Carrying Insects: “Agriculture Research Service (ARS) ( )” USDA (Stephen Ausmus) / Public domain (cropped)
- Related lab (放射
線動物科学研究室): “Individually cage for lab mice” Karol Głąb (Karol007) / CC BY-SA 3.0 (cropped) - Related lab (応用遺伝学研究室): “GFP Mice 01” Ingrid Moen, Charlotte Jevne, Jian Wang, Karl-Henning Kalland, Martha Chekenya, Lars A Akslen, Linda Sleire, Per Ø Enger / CC BY 2.0 (cropped)
- Related lab (産業技術総合研究所): “Brainbow (Smith 2007)” Stephen J Smith / CC BY 3.0 (cropped)
- Related lab (獣
医動物 行動学研究室): “Laboratory rat” Anna Marchenkova / CC BY 4.0 (cropped)
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